{"id":"46097102-8e9d-50d9-9e52-3ba4826be182","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-formulation-exposure","predicate":"formulation_changes","statement":"The tested water-soluble formulation had 2.4-fold higher baseline-corrected exposure than standard ubiquinone capsules; the ubiquinol-capsule comparison was not statistically significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5f79e21d-f2b9-5782-9204-2c5102f25a72","mechanism_event_label":"The formulation mattered; the redox-form label alone did not establish superiority.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f79e21d-f2b9-5782-9204-2c5102f25a72","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-formulation-exposure-event","event_type":"observed_intervention","label":"The formulation mattered; the redox-form label alone did not establish superiority.","description":"The tested water-soluble formulation had 2.4-fold higher baseline-corrected exposure than standard ubiquinone capsules; the ubiquinol-capsule comparison was not statistically significant.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"64f0151b-6c0d-5adf-a6b4-13056bc8dfb3","slug":"ubiquinone-10","display_name":"Ubiquinone-10","entity_type_key":"small_molecule"},"role":"tested_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64fbe9b3-bf24-5b66-9611-8b78262d6ffc","slug":"reduced-coq10","display_name":"Reduced CoQ10","entity_type_key":"small_molecule"},"role":"tested_form","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/32188111.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"651570863e9a81a09c85040d74da26366d5b9f94145d97cac6aad48378597ce6\", \"start_char\": 0, \"end_char\": 1662, \"text_sha256\": \"651570863e9a81a09c85040d74da26366d5b9f94145d97cac6aad48378597ce6\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized three-period crossover pharmacokinetic study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Single equivalent 100-mg doses in three formulations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small single-dose formulation comparison; plasma exposure is not tissue delivery or clinical efficacy. Product-specific findings cannot rank every ubiquinone or ubiquinol product.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"21 healthy adults aged 65-74","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The formulation mattered; the redox-form label alone did not establish superiority.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p32188111] Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. (2020). https://pubmed.ncbi.nlm.nih.gov/32188111/ DOI: 10.3390/nu12030784","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma total CoQ and redox state over 48 hours","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"97c4ffcc-c0ae-570b-8542-854f5cdd7188","evidence_kind":"source_excerpt","locator":"Lines 879-890","start_line":879,"end_line":890,"excerpt":"### coq10-formulation-exposure\nThe tested water-soluble formulation had 2.4-fold higher baseline-corrected exposure than standard ubiquinone capsules; the ubiquinol-capsule comparison was not statistically significant.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The formulation mattered; the redox-form label alone did not establish superiority.\norganism: 21 healthy adults aged 65-74\ntissue_or_cell_type: Plasma total CoQ and redox state over 48 hours\nexperimental_model: Randomized three-period crossover pharmacokinetic study\nlimitations: Small single-dose formulation comparison; plasma exposure is not tissue delivery or clinical efficacy. Product-specific findings cannot rank every ubiquinone or ubiquinol product.\nexposure: Single equivalent 100-mg doses in three formulations\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/32188111.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"651570863e9a81a09c85040d74da26366d5b9f94145d97cac6aad48378597ce6\", \"start_char\": 0, \"end_char\": 1662, \"text_sha256\": \"651570863e9a81a09c85040d74da26366d5b9f94145d97cac6aad48378597ce6\"}\n[coq10-p32188111] Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. (2020). https://pubmed.ncbi.nlm.nih.gov/32188111/ DOI: 10.3390/nu12030784","model_system":"Randomized three-period crossover pharmacokinetic study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p32188111] Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. (2020). https://pubmed.ncbi.nlm.nih.gov/32188111/ DOI: 10.3390/nu12030784","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}