{"id":"45e37bd8-1d4a-547c-ac7a-934c94a76a98","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-ca-differential-pth-secretory-potency","predicate":"inhibits","statement":"In bovine parathyroid slices, extracellular Mg and Ca inhibited PTH release additively, but Mg was less potent on a molar basis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fad2a170-6fa5-5f4c-afe5-2aaa7ac6dfe9","mechanism_event_label":"Both ions can signal the gland to release less PTH; calcium and magnesium are not interchangeable inputs.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fad2a170-6fa5-5f4c-afe5-2aaa7ac6dfe9","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-ca-differential-pth-secretory-potency-event","event_type":"biochemical_relationship","label":"Both ions can signal the gland to release less PTH; calcium and magnesium are not interchangeable inputs.","description":"In bovine parathyroid slices, extracellular Mg and Ca inhibited PTH release additively, but Mg was less potent on a molar basis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"co-regulatory ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"secreted hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Graded extracellular cations in cultured bovine parathyroid slices","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Potency depends on concentrations and preparation; no general human replacement ratio follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Bos taurus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Both ions can signal the gland to release less PTH; calcium and magnesium are not interchangeable inputs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[habener-1976-pth-synthesis-secretion] Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro (1976). https://pubmed.ncbi.nlm.nih.gov/1248443/ DOI: 10.1210/endo-98-1-197","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Parathyroid gland","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7a239e4d-fcf4-5300-ae9b-3de23ada4cc2","evidence_kind":"source_excerpt","locator":"Lines 253-263","start_line":253,"end_line":263,"excerpt":"### mg-ca-differential-pth-secretory-potency\nIn bovine parathyroid slices, extracellular Mg and Ca inhibited PTH release additively, but Mg was less potent on a molar basis.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Both ions can signal the gland to release less PTH; calcium and magnesium are not interchangeable inputs.\norganism: Bos taurus\ntissue_or_cell_type: Parathyroid gland\nexperimental_model: Graded extracellular cations in cultured bovine parathyroid slices\nlimitations: Potency depends on concentrations and preparation; no general human replacement ratio follows.\ncross_nutrient: magnesium -> PTH -> calcium\n[habener-1976-pth-synthesis-secretion] Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro (1976). https://pubmed.ncbi.nlm.nih.gov/1248443/ DOI: 10.1210/endo-98-1-197","model_system":"Graded extracellular cations in cultured bovine parathyroid slices","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [habener-1976-pth-synthesis-secretion] Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro (1976). https://pubmed.ncbi.nlm.nih.gov/1248443/ DOI: 10.1210/endo-98-1-197","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}