{"id":"45ddf710-ebdb-54f5-9fa8-e60915c7558f","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-renal-mouse-conservation","predicate":"restriction_induces","statement":"Two weeks of low-protein or low-sulfur-amino-acid feeding lowered plasma taurine and increased renal taurine uptake while reducing fractional urinary excretion in the studied mouse strains.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43a1d1db-5ce8-52c0-821b-e6e3f6453df5","mechanism_event_label":"The kidney conserved taurine when dietary supply of its precursors was restricted.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"d8812fb7-f008-5f9c-ac63-d506a4d8d9b1","slug":"mouse-renal-taurine-conservation","display_name":"Renal taurine conservation in dietary-restricted mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43a1d1db-5ce8-52c0-821b-e6e3f6453df5","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-renal-mouse-conservation-event","event_type":"observed_relationship","label":"The kidney conserved taurine when dietary supply of its precursors was restricted.","description":"Two weeks of low-protein or low-sulfur-amino-acid feeding lowered plasma taurine and increased renal taurine uptake while reducing fractional urinary excretion in the studied mouse strains.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d8812fb7-f008-5f9c-ac63-d506a4d8d9b1","slug":"mouse-renal-taurine-conservation","display_name":"Renal taurine conservation in dietary-restricted mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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