{"id":"453c260a-9552-5692-9298-65af8206ff06","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-oral-half-life","predicate":"has_study_specific","statement":"Mean elimination half-life was about 54 minutes after oral dosing and 39 minutes after intravenous dosing.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3eece403-0296-5a24-82f7-44235da41cdd","mechanism_event_label":"The hormone blood half-life is not the same as the duration of a shifted body clock.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"4d5ddb75-cac3-5e98-ad3f-f9b2b8e1035e","slug":"melatonin-plasma-elimination-half-life","display_name":"Melatonin plasma elimination half-life","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3eece403-0296-5a24-82f7-44235da41cdd","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-oral-half-life-event","event_type":"observed_intervention","label":"The hormone blood half-life is not the same as the duration of a shifted body clock.","description":"Mean elimination half-life was about 54 minutes after oral dosing and 39 minutes after intravenous dosing.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4d5ddb75-cac3-5e98-ad3f-f9b2b8e1035e","slug":"melatonin-plasma-elimination-half-life","display_name":"Melatonin plasma elimination half-life","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/26893170.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c\", \"start_char\": 0, \"end_char\": 1763, \"text_sha256\": \"adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral versus intravenous crossover pharmacokinetics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg oral and 10 mg intravenous on separate days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific immediate-release preparation and study population. Bioavailability varies by formulation and individual; not a dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Twelve healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The hormone blood half-life is not the same as the duration of a shifted body clock.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p26893170] Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. (2016). https://pubmed.ncbi.nlm.nih.gov/26893170/ DOI: 10.1186/s40360-016-0052-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma exposure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f3d8bc3d-1832-5038-b585-c973824aa31d","evidence_kind":"source_excerpt","locator":"Lines 682-693","start_line":682,"end_line":693,"excerpt":"### melatonin-oral-half-life\nMean elimination half-life was about 54 minutes after oral dosing and 39 minutes after intravenous dosing.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The hormone blood half-life is not the same as the duration of a shifted body clock.\norganism: Twelve healthy men\ntissue_or_cell_type: Plasma exposure\nexperimental_model: Oral versus intravenous crossover pharmacokinetics\nlimitations: Specific immediate-release preparation and study population. Bioavailability varies by formulation and individual; not a dosing recommendation.\nexposure: 10 mg oral and 10 mg intravenous on separate days\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/26893170.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c\", \"start_char\": 0, \"end_char\": 1763, \"text_sha256\": \"adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c\"}\n[melatonin-p26893170] Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. (2016). https://pubmed.ncbi.nlm.nih.gov/26893170/ DOI: 10.1186/s40360-016-0052-2","model_system":"Oral versus intravenous crossover pharmacokinetics","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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