{"id":"45236eb0-dc53-54ef-be80-8e31cd330b6f","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-rat-butyrate","predicate":"associated_with","statement":"Myricetin altered butyrate-associated gut microbial composition alongside reduced hepatic lipid synthesis and inflammation in high-fat-fed rats.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b03d0814-7ae5-5be1-ab19-e7078cc3fca6","mechanism_event_label":"Gut effects may help explain activity despite limited systemic exposure.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"c6574f0a-309c-5413-a7df-1458c7238803","slug":"rat-fecal-butyrate-microbiota","display_name":"Rat fecal butyrate-associated microbial composition","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b03d0814-7ae5-5be1-ab19-e7078cc3fca6","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-rat-butyrate-event","event_type":"observed_relationship","label":"Gut effects may help explain activity despite limited systemic exposure.","description":"Myricetin altered butyrate-associated gut microbial composition alongside reduced hepatic lipid synthesis and inflammation in high-fat-fed rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6574f0a-309c-5413-a7df-1458c7238803","slug":"rat-fecal-butyrate-microbiota","display_name":"Rat fecal butyrate-associated microbial composition","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve-week rat supplementation study with fecal transplantation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Taxa or fecal concentration do not alone establish production flux, a specific strain enzyme, or butyrate as the sole mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Gut effects may help explain activity despite limited systemic exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34469716/ · DOI 10.1016/j.celrep.2021.109641","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cb805a9b-971a-5f6a-b9fe-b119b823f5bc","evidence_kind":"source_excerpt","locator":"Lines 540-546","start_line":540,"end_line":546,"excerpt":"## myricetin-rat-butyrate\nGut effects may help explain activity despite limited systemic exposure.\nMyricetin altered butyrate-associated gut microbial composition alongside reduced hepatic lipid synthesis and inflammation in high-fat-fed rats.\nModel: Twelve-week rat supplementation study with fecal transplantation.\nLimitations: Taxa or fecal concentration do not alone establish production flux, a specific strain enzyme, or butyrate as the sole mediator.\nEvidence access: Primary abstract\nMyricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34469716/ · DOI 10.1016/j.celrep.2021.109641","model_system":"Twelve-week rat supplementation study with fecal transplantation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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