{"id":"4507002c-b843-5dc3-b420-94621559c952","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:sleep-deprivation-performance","predicate":"context_dependent_observation","statement":"Modafinil improved vigilance and objective alertness in human sleep deprivation, while executive-function effects differed by task.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cba63499-e014-57ab-b971-6d5e6297f6bb","mechanism_event_label":"Modafinil improved vigilance and objective alertness in human sleep deprivation, while executive-function effects differed by task.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"4497a61f-f047-57b3-8842-8df0ce8d370f","slug":"cognitive-task-performance","display_name":"Cognitive task performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cba63499-e014-57ab-b971-6d5e6297f6bb","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:sleep-deprivation-performance-event","event_type":"experimental_observation","label":"Modafinil improved vigilance and objective alertness in human sleep deprivation, while executive-function effects differed by task.","description":"In a human sleep-deprivation comparison, modafinil, caffeine and dextroamphetamine improved vigilance and objective alertness relative to placebo. Executive-function results differed by task. The experiment supports temporary performance mitigation, not preserved judgment across every task or indefinite replacement of sleep. 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