{"id":"44fa2294-c02b-5ccd-bd83-86695c41a1e3","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-aggregate-toxicity","predicate":"reduces","statement":"Remodeled aggregates had lower toxicity in the tested cell assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"0d1a75eb-e323-5168-a029-2e3b54d1ecdd","mechanism_event_label":"The remodeled material was less harmful in that assay.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"dd2cd116-a7e9-51fc-b530-9c6893b008a8","slug":"amyloid-aggregate-cell-toxicity","display_name":"Amyloid aggregate toxicity in cell assays","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d1a75eb-e323-5168-a029-2e3b54d1ecdd","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-aggregate-toxicity-event","event_type":"observed_relationship","label":"The remodeled material was less harmful in that assay.","description":"Remodeled aggregates had lower toxicity in the tested cell assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dd2cd116-a7e9-51fc-b530-9c6893b008a8","slug":"amyloid-aggregate-cell-toxicity","display_name":"Amyloid aggregate toxicity in cell assays","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Cell toxicity comparison of treated versus untreated fibrils.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay result, not clinical cognitive improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The remodeled material was less harmful in that assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20385841/ · DOI 10.1073/pnas.0910723107","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"73a8b6b2-cb64-5986-b4ac-005b9ecc2d18","evidence_kind":"source_excerpt","locator":"Lines 372-378","start_line":372,"end_line":378,"excerpt":"## egcg-aggregate-toxicity\nThe remodeled material was less harmful in that assay.\nRemodeled aggregates had lower toxicity in the tested cell assay.\nModel: Cell toxicity comparison of treated versus untreated fibrils.\nLimitations: Assay result, not clinical cognitive improvement.\nEvidence access: primary abstract.\nEGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20385841/ · DOI 10.1073/pnas.0910723107","model_system":"Cell toxicity comparison of treated versus untreated fibrils.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}