{"id":"43daedff-8cd7-5815-b3a2-8c9d64676ce0","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-nqo1","predicate":"increases_expression","statement":"Mangiferin increased NQO1 expression in cord-blood mononuclear cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bb3605e9-390c-509f-bd91-5389bceec763","mechanism_event_label":"A quinone-processing defense enzyme responded.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"01f73291-ab25-59e2-a5e9-71d15a6c2a0a","slug":"nqo1","display_name":"Human NAD(P)H quinone dehydrogenase 1 / NQO1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"bb3605e9-390c-509f-bd91-5389bceec763","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-nqo1-event","event_type":"biochemical_relationship","label":"A quinone-processing defense enzyme responded.","description":"Mangiferin increased NQO1 expression in cord-blood mononuclear cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"01f73291-ab25-59e2-a5e9-71d15a6c2a0a","slug":"nqo1","display_name":"Human NAD(P)H quinone dehydrogenase 1 / NQO1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/25380307.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\", \"start_char\": 0, \"end_char\": 1636, \"text_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated human cord-blood mononuclear cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin and etoposide; concentration not specified in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A quinone-processing defense enzyme responded.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cord-blood mononuclear cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bc12735d-d4f1-5913-ac68-c90bb9f33314","evidence_kind":"source_excerpt","locator":"Lines 575-586","start_line":575,"end_line":586,"excerpt":"### mangiferin-nqo1\nMangiferin increased NQO1 expression in cord-blood mononuclear cells.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A quinone-processing defense enzyme responded.\norganism: Homo sapiens\ntissue_or_cell_type: Cord-blood mononuclear cells\nexperimental_model: Isolated human cord-blood mononuclear cells\nlimitations: Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection.\nexposure: Mangiferin and etoposide; concentration not specified in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/25380307.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\", \"start_char\": 0, \"end_char\": 1636, \"text_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\"}\n[mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","model_system":"Isolated human cord-blood mononuclear cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}