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It establishes the selenium-containing active site; it is not a statement about selenium intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat and human enzyme","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The enzyme’s working end is built from a selenium amino acid paired with a cysteine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p10801974] Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. 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It establishes the selenium-containing active site; it is not a statement about selenium intake.\nexposure: Oxidised and NADPH-reduced enzyme states\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/10801974.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1627b8b48962b6d2b9bead351b64b71fb60b9681378b44f77a3fc288d35119e3\", \"start_char\": 0, \"end_char\": 1719, \"text_sha256\": \"1627b8b48962b6d2b9bead351b64b71fb60b9681378b44f77a3fc288d35119e3\"}\n[hbot-p10801974] Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. 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