{"id":"439f34a1-8874-516a-9060-60c43cc79b4d","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-microbial-conversion","predicate":"converted_to","statement":"Human fecal fermentation converted EGCG through ester hydrolysis, ring opening/fission and subsequent reactions to phenolic acids, including 4-phenylbutyric and hydroxyphenylpropionic acids.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"24c7678f-5e40-5553-bd0f-cbf71057fe32","mechanism_event_label":"Gut microbes can turn EGCG into chemically different compounds.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"a11cdf8a-6173-5910-81ce-140fccf673b1","slug":"egcg-gut-metabolites","display_name":"EGCG-derived microbial phenolic metabolite pool","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"24c7678f-5e40-5553-bd0f-cbf71057fe32","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-microbial-conversion-event","event_type":"observed_relationship","label":"Gut microbes can turn EGCG into chemically different compounds.","description":"Human fecal fermentation converted EGCG through ester hydrolysis, ring opening/fission and subsequent reactions to phenolic acids, including 4-phenylbutyric and hydroxyphenylpropionic acids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a11cdf8a-6173-5910-81ce-140fccf673b1","slug":"egcg-gut-metabolites","display_name":"EGCG-derived microbial phenolic metabolite pool","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"In-vitro human gut-community fermentation and UHPLC-Q-Orbitrap-MS.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Metabolite detection in fermentation does not demonstrate systemic human exposure or benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Gut microbes can turn EGCG into chemically different compounds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32808768/ · DOI 10.1021/acs.jafc.0c03587","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f6106c5a-a55d-5ba3-9000-ac00bfe9a909","evidence_kind":"source_excerpt","locator":"Lines 316-322","start_line":316,"end_line":322,"excerpt":"## egcg-microbial-conversion\nGut microbes can turn EGCG into chemically different compounds.\nHuman fecal fermentation converted EGCG through ester hydrolysis, ring opening/fission and subsequent reactions to phenolic acids, including 4-phenylbutyric and hydroxyphenylpropionic acids.\nModel: In-vitro human gut-community fermentation and UHPLC-Q-Orbitrap-MS.\nLimitations: Metabolite detection in fermentation does not demonstrate systemic human exposure or benefit.\nEvidence access: primary abstract.\nReciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32808768/ · DOI 10.1021/acs.jafc.0c03587","model_system":"In-vitro human gut-community fermentation and UHPLC-Q-Orbitrap-MS.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}