{"id":"436d9b9a-c1e8-5786-a00a-127543b56bc0","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mettl16-feedback","predicate":"promotes_under_low_sam","statement":"Methionine-starvation-induced SAM depletion increased MAT2A expression through METTL16-dependent splicing involving a conserved 3-prime-UTR hairpin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9096c47e-63d2-5f27-ad58-f582b30c7696","mechanism_event_label":"Low methyl-donor availability can increase production capacity through RNA processing.","subject":{"id":"466b1102-12e9-5241-a335-59fdf4152ef4","slug":"mettl16","display_name":"Human RNA methyltransferase / METTL16","entity_type_key":"protein"},"object":{"id":"26ac45da-ff96-5b2d-97ab-fdd9938aa5b2","slug":"human-mat2a-intron-splicing","display_name":"Splicing of the retained human MAT2A intron","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9096c47e-63d2-5f27-ad58-f582b30c7696","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mettl16-feedback-event","event_type":"observed_relationship","label":"Low methyl-donor availability can increase production capacity through RNA processing.","description":"Methionine-starvation-induced SAM depletion increased MAT2A expression through METTL16-dependent splicing involving a conserved 3-prime-UTR hairpin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"466b1102-12e9-5241-a335-59fdf4152ef4","slug":"mettl16","display_name":"Human RNA methyltransferase / METTL16","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"26ac45da-ff96-5b2d-97ab-fdd9938aa5b2","slug":"human-mat2a-intron-splicing","display_name":"Splicing of the retained human MAT2A intron","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"bbc04455-e242-5f4d-9a6c-5b2ee6a6cb41","slug":"human-mat2a","display_name":"Human methionine adenosyltransferase 2A / MAT2A","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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