{"id":"430ae1ef-c44b-5a1b-8018-be2d86b47620","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-glycogen-muscle","predicate":"reduces","statement":"Muscle glycogen content was approximately halved.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"eed5a8ee-133c-5b71-a924-52c83e286103","mechanism_event_label":"Muscle retained some carbohydrate reserve.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"8ead1330-6fcd-50f4-90d3-4b7b6f0d085c","slug":"skeletal-muscle-glycogen-content","display_name":"Skeletal-muscle glycogen content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eed5a8ee-133c-5b71-a924-52c83e286103","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-glycogen-muscle-event","event_type":"observed_relationship","label":"Muscle retained some carbohydrate reserve.","description":"Muscle glycogen content was approximately halved.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8ead1330-6fcd-50f4-90d3-4b7b6f0d085c","slug":"skeletal-muscle-glycogen-content","display_name":"Skeletal-muscle glycogen content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thirteen adults; seven-day fast, muscle biopsies and exercise testing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is muscle glycogen, not a measurement of hepatic glycogen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Muscle retained some carbohydrate reserve.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39747857/ · DOI 10.1038/s41467-024-55418-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8c8307d4-c8ae-535e-8d88-8c2dd2fdad4b","evidence_kind":"source_excerpt","locator":"Lines 200-206","start_line":200,"end_line":206,"excerpt":"## fast-glycogen-muscle\nMuscle retained some carbohydrate reserve.\nMuscle glycogen content was approximately halved.\nModel: Thirteen adults; seven-day fast, muscle biopsies and exercise testing.\nLimitations: This is muscle glycogen, not a measurement of hepatic glycogen.\nEvidence access: Primary abstract\nEffects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39747857/ · DOI 10.1038/s41467-024-55418-0","model_system":"Thirteen adults; seven-day fast, muscle biopsies and exercise testing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}