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(2024). https://pubmed.ncbi.nlm.nih.gov/39493360/ DOI: 10.1177/11795549241283421","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Six cell lines; MDA-MB-231 xenografts","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"14768fde-26ae-553d-8b83-16c779446aea","evidence_kind":"source_excerpt","locator":"Lines 1092-1103","start_line":1092,"end_line":1103,"excerpt":"### ala-ascorbate-tumor-response\nLower tested lipoic-acid doses attenuated tumor-growth inhibition from high-dose ascorbate in the mouse model; the highest dose did not enhance it.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combination did not provide a universal antioxidant synergy.\norganism: Human cancer cells and mice\ntissue_or_cell_type: Six cell lines; MDA-MB-231 xenografts\nexperimental_model: Cancer-cell combinations and human-tumor xenograft experiments\nlimitations: Pharmacological ascorbate and animal injection exposures are not dietary vitamin C; no clinical combination trial.\nexposure: Millimolar cell exposures; injected ALA/ascorbate combinations in mice\nevidence_span: {\"source_cache\": \"artifacts/ala-research/39493360.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266\", \"start_char\": 0, \"end_char\": 1935, \"text_sha256\": \"9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266\"}\n[ala-p39493360] Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models. 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