{"id":"42b15013-51c7-55ba-975d-5ffed3eca9bf","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-rumen-thiomolybdates","predicate":"is_converted_in_sheep_rumen_to","statement":"Radiotracer experiments directly detected tri- and tetrathiomolybdate formation in the sheep rumen after molybdate administration.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b1bc2e21-be05-54b9-bb74-c85b22607f6c","mechanism_event_label":"Rumen microbes create copper-interacting forms under these animal conditions.","subject":{"id":"18479412-e52f-5921-8b5a-ddacefcbe083","slug":"molybdate","display_name":"Molybdate / MoO4(2-)","entity_type_key":"ion"},"object":{"id":"73a56883-7a7a-5377-b731-a5e066d79fbc","slug":"tetrathiomolybdate","display_name":"Tetrathiomolybdate / MoS4(2-)","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"b1bc2e21-be05-54b9-bb74-c85b22607f6c","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-rumen-thiomolybdates-event","event_type":"biochemical_relationship","label":"Rumen microbes create copper-interacting forms under these animal conditions.","description":"Radiotracer experiments directly detected tri- and tetrathiomolybdate formation in the sheep rumen after molybdate administration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"18479412-e52f-5921-8b5a-ddacefcbe083","slug":"molybdate","display_name":"Molybdate / MoO4(2-)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"73a56883-7a7a-5377-b731-a5e066d79fbc","slug":"tetrathiomolybdate","display_name":"Tetrathiomolybdate / MoS4(2-)","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/3620434.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ef45902ca0d465ae0c4c59c2f669a74137ba1b0f64d7aff5502c2cf57154ef25\", \"start_char\": 0, \"end_char\": 1324, \"text_sha256\": \"ef45902ca0d465ae0c4c59c2f669a74137ba1b0f64d7aff5502c2cf57154ef25\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Radiolabeled molybdate/thiomolybdate administered into sheep rumen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Grass diet plus intraruminal 99Mo compounds","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ruminant sulfur chemistry cannot be assumed to occur to the same extent in the human gut.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Ovis aries","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Rumen microbes create copper-interacting forms under these animal conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p3620434] Identification of thiomolybdates in digesta and plasma from sheep after administration of 99Mo-labelled compounds into the rumen. (1987). https://pubmed.ncbi.nlm.nih.gov/3620434/ DOI: 10.1079/bjn19870076","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Rumen, intestinal digesta and plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a5019780-f2c1-5225-8b83-d99568724877","evidence_kind":"source_excerpt","locator":"Lines 1626-1637","start_line":1626,"end_line":1637,"excerpt":"### mo-rumen-thiomolybdates\nRadiotracer experiments directly detected tri- and tetrathiomolybdate formation in the sheep rumen after molybdate administration.\nCondition category: normal\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Rumen microbes create copper-interacting forms under these animal conditions.\norganism: Ovis aries\ntissue_or_cell_type: Rumen, intestinal digesta and plasma\nexperimental_model: Radiolabeled molybdate/thiomolybdate administered into sheep rumen\nlimitations: Ruminant sulfur chemistry cannot be assumed to occur to the same extent in the human gut.\nexposure: Grass diet plus intraruminal 99Mo compounds\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/3620434.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ef45902ca0d465ae0c4c59c2f669a74137ba1b0f64d7aff5502c2cf57154ef25\", \"start_char\": 0, \"end_char\": 1324, \"text_sha256\": \"ef45902ca0d465ae0c4c59c2f669a74137ba1b0f64d7aff5502c2cf57154ef25\"}\n[mo-p3620434] Identification of thiomolybdates in digesta and plasma from sheep after administration of 99Mo-labelled compounds into the rumen. (1987). https://pubmed.ncbi.nlm.nih.gov/3620434/ DOI: 10.1079/bjn19870076","model_system":"Radiolabeled molybdate/thiomolybdate administered into sheep rumen","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mo-p3620434] Identification of thiomolybdates in digesta and plasma from sheep after administration of 99Mo-labelled compounds into the rumen. (1987). https://pubmed.ncbi.nlm.nih.gov/3620434/ DOI: 10.1079/bjn19870076","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1aa6da60-8284-5252-8dd9-ac2250d5ced5","stable_key":"import-dc8975b1-95ff-5d9b-be17-a1c04610cca7","title":"Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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