{"id":"427eb2a3-420a-5c07-9e78-bc5dd3d2a7dc","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-hpp-pediatric-pyridoxal","predicate":"deficiency_associated_with_elevated_pediatric_pyridoxal","statement":"In 150 affected children/adolescents, mean plasma pyridoxal was 66.7 versus 37.1 nM in controls; mean 4-pyridoxic acid did not differ.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"bc6fe5ce-a58e-57b1-b008-a3bb6e17de75","mechanism_event_label":"ALPL impairment did not make circulating pyridoxal universally low in this pediatric cohort.","subject":{"id":"3148c377-9b4c-56ca-bc36-081bf1905d57","slug":"alpl","display_name":"Tissue-nonspecific alkaline phosphatase ALPL / TNAP","entity_type_key":"protein"},"object":{"id":"9bf6269d-9e01-553d-bd8b-11a0d613bfca","slug":"pyridoxal","display_name":"Pyridoxal","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"bc6fe5ce-a58e-57b1-b008-a3bb6e17de75","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-hpp-pediatric-pyridoxal-event","event_type":"observed_intervention","label":"ALPL impairment did not make circulating pyridoxal universally low in this pediatric cohort.","description":"In 150 affected children/adolescents, mean plasma pyridoxal was 66.7 versus 37.1 nM in controls; mean 4-pyridoxic acid did not differ.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"befbcf98-c6a9-5b72-a039-2d6b9f3bde12","slug":"4-pyridoxic-acid","display_name":"4-Pyridoxic acid","entity_type_key":"small_molecule"},"role":"catabolite_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3148c377-9b4c-56ca-bc36-081bf1905d57","slug":"alpl","display_name":"Tissue-nonspecific alkaline phosphatase ALPL / TNAP","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9bf6269d-9e01-553d-bd8b-11a0d613bfca","slug":"pyridoxal","display_name":"Pyridoxal","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Primary measurement study in 150 children/adolescents with hypophosphatasia and healthy pediatric comparators; 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unverified.","entity":null}],"evidence":[{"id":"92dbde4a-eebb-5f07-a265-1c0fa8a8db4d","evidence_kind":"source_excerpt","locator":"Lines 1633-1643","start_line":1633,"end_line":1643,"excerpt":"### b6-hpp-pediatric-pyridoxal\nIn 150 affected children/adolescents, mean plasma pyridoxal was 66.7 versus 37.1 nM in controls; mean 4-pyridoxic acid did not differ.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: ALPL impairment did not make circulating pyridoxal universally low in this pediatric cohort.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Primary measurement study in 150 children/adolescents with hypophosphatasia and healthy pediatric comparators; adult observations separately discussed.\nlimitations: Cohort result cannot be transferred to every severe neonatal case; does not establish all-tissue sufficiency.\nexposure: ALPL-related hypophosphatasia, variable clinical severity; plasma vitamers, not direct all-tissue cofactor measurement.\n[b6-whyte2022] Hypophosphatasia: Vitamin B6 status of affected children and adults (2022). https://pubmed.ncbi.nlm.nih.gov/34547524/ DOI: 10.1016/j.bone.2021.116204","model_system":"Primary measurement study in 150 children/adolescents with hypophosphatasia and healthy pediatric comparators; adult observations separately discussed.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-whyte2022] Hypophosphatasia: Vitamin B6 status of affected children and adults (2022). https://pubmed.ncbi.nlm.nih.gov/34547524/ DOI: 10.1016/j.bone.2021.116204","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}