{"id":"425c6317-a737-543b-ad1b-93d4ea4fb3f2","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:cysteine-samc","predicate":"reported_relationship","statement":"Allicin reacted with L-cysteine to form the identified mixed-disulfide product SAMC.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a6fe495a-b901-5339-a518-6e43460da4a2","mechanism_event_label":"Allicin reacted with L-cysteine to form the identified mixed-disulfide product SAMC.","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"bec2dfe8-4aaf-5c12-9c6c-dd779e55c041","slug":"s-allylmercaptocysteine","display_name":"S-Allylmercapto-L-cysteine / SAMC","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a6fe495a-b901-5339-a518-6e43460da4a2","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:cysteine-samc-event","event_type":"biochemical_relationship","label":"Allicin reacted with L-cysteine to form the identified mixed-disulfide product SAMC.","description":"**Chemical identity.** Allicin is diallyl thiosulfinate, C6H10OS2, approximately 162.27 g/mol, with the structure CH2=CH–CH2–S(=O)–S–CH2–CH=CH2. The oxygen-containing thiosulfinate linkage matters: allicin is not diallyl disulfide, and the compounds cannot share target effects merely because both contain sulfur. Primary chemistry identified S-allylmercaptocysteine when allicin reacted with L-cysteine. [Rabinkov 1998](https://pubmed.ncbi.nlm.nih.gov/9528659/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"bec2dfe8-4aaf-5c12-9c6c-dd779e55c041","slug":"s-allylmercaptocysteine","display_name":"S-Allylmercapto-L-cysteine / SAMC","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"reacting thiol substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free chemical reaction; NMR characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Allicin reacted with L-cysteine to form the identified mixed-disulfide product SAMC.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. | 1998 | DOI 10.1016/s0304-4165(97)00104-9 | PMID 9528659 | https://pubmed.ncbi.nlm.nih.gov/9528659/ | https://doi.org/10.1016/s0304-4165(97)00104-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 9-9; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"30e52ea2-52e7-5a0b-86b9-587175da4cdd","evidence_kind":"source_excerpt","locator":"Lines 9-9","start_line":9,"end_line":9,"excerpt":"**Chemical identity.** Allicin is diallyl thiosulfinate, C6H10OS2, approximately 162.27 g/mol, with the structure CH2=CH–CH2–S(=O)–S–CH2–CH=CH2. The oxygen-containing thiosulfinate linkage matters: allicin is not diallyl disulfide, and the compounds cannot share target effects merely because both contain sulfur. Primary chemistry identified S-allylmercaptocysteine when allicin reacted with L-cysteine. [Rabinkov 1998](https://pubmed.ncbi.nlm.nih.gov/9528659/)","model_system":"Cell-free chemical reaction; NMR characterization.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}