{"id":"423cc0ca-ef92-5ff5-b494-9c2bf76d9e82","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-hla-oligomers","predicate":"reduces_oligomerization","statement":"Myricetin interfered with deoxycholate-induced Hla oligomerization and reduced hemolytic activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"138e851a-e777-5193-b21f-2d9e5e2bbac3","mechanism_event_label":"Toxin molecules need to assemble to form effective pores.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"2e690bef-73d5-587d-9b1c-0a91a984a6c4","slug":"staphylococcus-aureus-hla","display_name":"Staphylococcus aureus alpha-hemolysin / Hla","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"138e851a-e777-5193-b21f-2d9e5e2bbac3","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-hla-oligomers-event","event_type":"observed_relationship","label":"Toxin molecules need to assemble to form effective pores.","description":"Myricetin interfered with deoxycholate-induced Hla oligomerization and reduced hemolytic activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2e690bef-73d5-587d-9b1c-0a91a984a6c4","slug":"staphylococcus-aureus-hla","display_name":"Staphylococcus aureus alpha-hemolysin / Hla","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified toxin assembly and hemolysis assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Molecular specificity and clinically achievable exposure remain open.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Toxin molecules need to assemble to form effective pores.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32793508/ · DOI 10.3389/fcimb.2020.00330","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"84718faf-e26e-58ca-8a76-8e5c1a374600","evidence_kind":"source_excerpt","locator":"Lines 604-610","start_line":604,"end_line":610,"excerpt":"## myricetin-hla-oligomers\nToxin molecules need to assemble to form effective pores.\nMyricetin interfered with deoxycholate-induced Hla oligomerization and reduced hemolytic activity.\nModel: Purified toxin assembly and hemolysis assays.\nLimitations: Molecular specificity and clinically achievable exposure remain open.\nEvidence access: Primary full text\nA Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32793508/ · DOI 10.3389/fcimb.2020.00330","model_system":"Purified toxin assembly and hemolysis assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}