{"id":"421a31e3-5a1d-52a0-9ffc-c6ead8aa542f","stable_key":"pe-circuit-convergence-hypothesis","predicate":"may_converge_on","statement":"SELENOI, GPX4, and SELENOK may converge on phosphatidylethanolamine synthesis, protection, and calcium-linked peroxidation control.","claim_class":"hypothesis_link","status":"hypothesis","evidence_grade":"unverified_cross_path_inference","direction":"context_dependent","is_public":true,"mechanism_event_id":null,"mechanism_event_label":null,"subject":{"id":"83ea17c8-4611-596b-9be8-1a0df1c9b42e","slug":"selenok","display_name":"SELENOK","entity_type_key":"protein"},"object":{"id":"be4a52f4-f31c-59b7-b0da-4178fbb069c8","slug":"phosphatidylethanolamine","display_name":"Phosphatidylethanolamine","entity_type_key":"lipid"},"evidence_count":1,"mechanism_event":null,"contexts":[],"evidence":[{"id":"af47e57d-1b11-57fd-a4c9-334084574884","evidence_kind":"source_passage","locator":"lines 446-448","start_line":446,"end_line":448,"excerpt":"**4. The PE circuit.**\n\nSELENOI **makes** PE. GPX4 **protects** PE. SELENOK **enables palmitoylation of IP3R**, which controls the Ca²⁺ flux that drives lipid peroxidation. Three selenoproteins, three different verbs, one lipid. SELENOI mutations cause **SPG81 spastic paraplegia**; GPX4 loss causes **interneuron death**. Both neurological, both PE. Nobody has assayed them as one circuit. **If I were hunting for something undiscovered, this is where I'd put the money.**","model_system":"Source draft; model details require primary-source verification","directness":"derived_inference","verification_status":"source_derived_draft","notes":"Proposed SELENOI, GPX4, SELENOK, calcium, and PE convergence.","relationship":"supports","weight":1.0,"link_notes":"Passage support from supplied draft; not yet primary-source verified.","source":{"id":"6b10bfa1-ddd0-52b1-b23e-4c02162b94ab","stable_key":"corrections","title":"Selenium corrections and deep dive","document_type":"user_supplied_markdown","citation_label":"Selenium correction and deep-dive draft","file_path":"X:\\metabolic-ledger\\source_material\\selenium-corrections-and-deep-dive.md","sha256":"ae0bf24b7d9e8b4c7cbc46ac00d84922f467530c1288def216c28640df9e0d00","revision_id":"4cec6304-35d7-5560-9133-e6ea689db838","review_status":"unverified_draft","notes":"Retained as supplied source material. Primary literature verification is still required."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}