{"id":"41fa9ef7-b2af-596c-bc5d-2c9cd877e9a3","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq6-model-rescue","predicate":"partly_rescues","statement":"CoQ treatment partly reversed apoptosis after Coq6 knockdown in podocyte and zebrafish models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d5028c2b-86b6-5680-b295-f317b82adde2","mechanism_event_label":"Replacing the carrier helped in models of a specific synthesis defect.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"b2dc0323-24a2-5578-823a-a0f166cc55f6","slug":"podocyte-apoptosis","display_name":"Podocyte apoptosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5028c2b-86b6-5680-b295-f317b82adde2","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-coq6-model-rescue-event","event_type":"biochemical_relationship","label":"Replacing the carrier helped in models of a specific synthesis defect.","description":"CoQ treatment partly reversed apoptosis after Coq6 knockdown in podocyte and zebrafish models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b2dc0323-24a2-5578-823a-a0f166cc55f6","slug":"podocyte-apoptosis","display_name":"Podocyte apoptosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/21540551.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f01d7d237328376c3eb1ed5a3c2c1ee7561d78fb3890101ab5e8eb678c64def\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"3f01d7d237328376c3eb1ed5a3c2c1ee7561d78fb3890101ab5e8eb678c64def\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human pedigrees, yeast validation, podocyte and zebrafish knockdown","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"COQ6 variants; cell/embryo knockdown and CoQ treatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The canonical podocyte process is the cell endpoint; zebrafish apoptosis was also studied. Partial model rescue is not universal clinical reversal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"13 humans from seven families plus model systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Replacing the carrier helped in models of a specific synthesis defect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p21540551] COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. (2011). https://pubmed.ncbi.nlm.nih.gov/21540551/ DOI: 10.1172/jci45693","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Renal podocytes and inner-ear disease","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a37b5ff4-7c29-5dc6-ad86-c4192393fd74","evidence_kind":"source_excerpt","locator":"Lines 1022-1033","start_line":1022,"end_line":1033,"excerpt":"### coq10-coq6-model-rescue\nCoQ treatment partly reversed apoptosis after Coq6 knockdown in podocyte and zebrafish models.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Replacing the carrier helped in models of a specific synthesis defect.\norganism: 13 humans from seven families plus model systems\ntissue_or_cell_type: Renal podocytes and inner-ear disease\nexperimental_model: Human pedigrees, yeast validation, podocyte and zebrafish knockdown\nlimitations: The canonical podocyte process is the cell endpoint; zebrafish apoptosis was also studied. Partial model rescue is not universal clinical reversal.\nexposure: COQ6 variants; cell/embryo knockdown and CoQ treatment\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/21540551.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f01d7d237328376c3eb1ed5a3c2c1ee7561d78fb3890101ab5e8eb678c64def\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"3f01d7d237328376c3eb1ed5a3c2c1ee7561d78fb3890101ab5e8eb678c64def\"}\n[coq10-p21540551] COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. (2011). https://pubmed.ncbi.nlm.nih.gov/21540551/ DOI: 10.1172/jci45693","model_system":"Human pedigrees, yeast validation, podocyte and zebrafish knockdown","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p21540551] COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. (2011). https://pubmed.ncbi.nlm.nih.gov/21540551/ DOI: 10.1172/jci45693","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}