{"id":"41d5730f-5039-50d6-9ab3-a200e37aa9b3","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-human-h2s","predicate":"increases","statement":"Taurine supplementation increased measured plasma hydrogen sulfide in the blood-pressure trial; changes in pressure were negatively correlated with H2S and taurine concentrations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"82614bf3-00be-59c7-b075-440ff798c940","mechanism_event_label":"The study linked the response to a sulfur signaling molecule.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"58330668-3d5d-5c91-b3a4-43b67c130db9","slug":"human-taurine-plasma-h2s","display_name":"Plasma hydrogen sulfide in the taurine blood-pressure trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"82614bf3-00be-59c7-b075-440ff798c940","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-human-h2s-event","event_type":"observed_relationship","label":"The study linked the response to a sulfur signaling molecule.","description":"Taurine supplementation increased measured plasma hydrogen sulfide in the blood-pressure trial; changes in pressure were negatively correlated with H2S and taurine concentrations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"58330668-3d5d-5c91-b3a4-43b67c130db9","slug":"human-taurine-plasma-h2s","display_name":"Plasma hydrogen sulfide in the taurine blood-pressure trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human randomized trial with biomarker correlations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlation within the trial does not prove H2S mediated the clinical blood-pressure effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The study linked the response to a sulfur signaling molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ea885f7c-1736-58c2-8dd4-7f2640cca1c3","evidence_kind":"source_excerpt","locator":"Lines 489-495","start_line":489,"end_line":495,"excerpt":"## taurine-human-h2s\nThe study linked the response to a sulfur signaling molecule.\nTaurine supplementation increased measured plasma hydrogen sulfide in the blood-pressure trial; changes in pressure were negatively correlated with H2S and taurine concentrations.\nModel: Human randomized trial with biomarker correlations.\nLimitations: Correlation within the trial does not prove H2S mediated the clinical blood-pressure effect.\nEvidence access: Primary abstract\nTaurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","model_system":"Human randomized trial with biomarker correlations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}