{"id":"41aa85c1-7a67-562f-bf41-790481cbaed4","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-biopsy-mineralization","predicate":"associated_with_preserved","statement":"Across 34 iliac biopsies after 2–60 months of ranelate treatment, secondary mineralization remained at a normal level while the bone area containing strontium increased.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"51d24ad8-6974-5faf-8bea-eabf4c42b313","mechanism_event_label":"A human biopsy series did not reproduce generalized mineralization failure.","subject":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"object":{"id":"428fd87b-12ad-5446-bf9f-63f8af3f162d","slug":"human-ranelate-bone-mineralization","display_name":"Degree of mineralization in human ranelate-treatment biopsies","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"51d24ad8-6974-5faf-8bea-eabf4c42b313","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-biopsy-mineralization-event","event_type":"observed_relationship","label":"A human biopsy series did not reproduce generalized mineralization failure.","description":"Across 34 iliac biopsies after 2–60 months of ranelate treatment, secondary mineralization remained at a normal level while the bone area containing strontium increased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"428fd87b-12ad-5446-bf9f-63f8af3f162d","slug":"human-ranelate-bone-mineralization","display_name":"Degree of mineralization in human ranelate-treatment biopsies","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d669dba0-d2a7-54ba-9641-542db7948422","slug":"human-new-bone-strontium-deposition","display_name":"Strontium deposition in newly formed human bone","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human iliac-bone microradiography and microanalysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Related clinical research program; not independent randomized proof of every cellular mechanism or absence of all adverse effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A human biopsy series did not reproduce generalized mineralization failure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21690207/ · DOI 10.1530/EJE-11-0415","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"de757cff-13d5-5909-ad6d-d2280c78989c","evidence_kind":"source_excerpt","locator":"Lines 302-308","start_line":302,"end_line":308,"excerpt":"## strontium-biopsy-mineralization\nA human biopsy series did not reproduce generalized mineralization failure.\nAcross 34 iliac biopsies after 2–60 months of ranelate treatment, secondary mineralization remained at a normal level while the bone area containing strontium increased.\nModel: Human iliac-bone microradiography and microanalysis.\nLimitations: Related clinical research program; not independent randomized proof of every cellular mechanism or absence of all adverse effects.\nEvidence access: Primary abstract\nDistribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21690207/ · DOI 10.1530/EJE-11-0415","model_system":"Human iliac-bone microradiography and microanalysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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