{"id":"415dce8d-e389-5a4d-a7e1-4d43b0d98891","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-cyp24a1-transcript","predicate":"low_supply_changes_transcript_abundance","statement":"Magnesium deprivation increased renal cyp24a1-mrna abundance in the 21-day rat experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8b6de52f-5401-5c80-9e53-852c3c599483","mechanism_event_label":"The message for a vitamin D breakdown enzyme rose.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"567706b1-8372-52f8-966b-f1f32176fc45","slug":"cyp24a1-mrna","display_name":"CYP24A1 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"8b6de52f-5401-5c80-9e53-852c3c599483","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-cyp24a1-transcript-event","event_type":"biochemical_relationship","label":"The message for a vitamin D breakdown enzyme rose.","description":"Magnesium deprivation increased renal cyp24a1-mrna abundance in the 21-day rat experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0a944e7-deb8-5f9e-8428-91496098e38f","slug":"cyp24a1","display_name":"Vitamin D 24-hydroxylase / CYP24A1","entity_type_key":"protein"},"role":"encoded_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; 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Study references: [mg-matsuzaki2013] Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats (2013). https://pubmed.ncbi.nlm.nih.gov/23816829/ DOI: 10.1684/mrh.2013.0341","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}