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A novel mechanism for defense against oxidative stress. (2003). https://pubmed.ncbi.nlm.nih.gov/12435734/ DOI: 10.1074/jbc.m210456200","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ubiquinone reduction","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"56e5c344-4cdb-5e0f-9598-d9f29a389d51","evidence_kind":"source_excerpt","locator":"Lines 788-799","start_line":788,"end_line":799,"excerpt":"### coq10-selenite-cell-recycling\nSelenite treatment increased cytosolic TrxR activity together with ubiquinone reduction in the tested cell homogenates.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A cell experiment connected selenium supply with CoQ recycling capacity.\norganism: Mammalian TrxR1 and human HEK293 cells\ntissue_or_cell_type: Ubiquinone reduction\nexperimental_model: Enzyme kinetics, mutants and overexpressing-cell homogenates\nlimitations: Cell-culture exposure; no clinical supplement ratio or systemic outcome was tested.\nexposure: NADPH or NADH; selenite and selenium-deprived enzyme variants\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/12435734.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"929e8de2bc15ea62eb4a3814995fd289de759d721f16b848174ad65f95847c55\", \"start_char\": 0, \"end_char\": 1340, \"text_sha256\": \"929e8de2bc15ea62eb4a3814995fd289de759d721f16b848174ad65f95847c55\"}\n[coq10-p12435734] The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. 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