{"id":"40af8fb2-4391-59ca-a122-8dde05d4fc5e","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-met-rat-xanthurenate","predicate":"constrains","statement":"Both B6-free rat diet groups showed substantially increased urinary xanthurenate relative to B6-containing groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5ea2941b-38a2-56b0-9ace-5f8697324def","mechanism_event_label":"B6 withdrawal diverted this urinary tryptophan-metabolism readout.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"32895c2c-b8d1-59a9-9728-109631f9c77e","slug":"urinary-xanthurenate-excretion","display_name":"Urinary xanthurenate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5ea2941b-38a2-56b0-9ace-5f8697324def","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-met-rat-xanthurenate-event","event_type":"observed_intervention","label":"B6 withdrawal diverted this urinary tryptophan-metabolism readout.","description":"Both B6-free rat diet groups showed substantially increased urinary xanthurenate relative to B6-containing groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6890a28f-385a-5352-9b3e-7d5e585a9925","slug":"xanthurenic-acid","display_name":"Xanthurenate","entity_type_key":"small_molecule"},"role":"urinary metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"32895c2c-b8d1-59a9-9728-109631f9c77e","slug":"urinary-xanthurenate-excretion","display_name":"Urinary xanthurenate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B6 and tryptophan metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young male Wistar rats; four controlled diets for 19 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"19-day controlled diets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The marker does not independently measure intracellular NAD.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"B6 withdrawal diverted this urinary tryptophan-metabolism readout.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-niacin-1995] Effects of Vitamin B6 Deficiency on the Conversion Ratio of Tryptophan to Niacin (1995). https://doi.org/10.1271/bbb.59.2060 DOI: 10.1271/bbb.59.2060","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2237b5e6-69b6-53c2-9873-0782047d8a56","evidence_kind":"source_excerpt","locator":"Lines 911-922","start_line":911,"end_line":922,"excerpt":"### b6-met-rat-xanthurenate\nBoth B6-free rat diet groups showed substantially increased urinary xanthurenate relative to B6-containing groups.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: B6 withdrawal diverted this urinary tryptophan-metabolism readout.\norganism: Rattus norvegicus\ntissue_or_cell_type: Urine\nexperimental_model: Young male Wistar rats; four controlled diets for 19 days\nlimitations: The marker does not independently measure intracellular NAD.\ncross_nutrient: B6 and tryptophan metabolism.\nexposure: 19-day controlled diets\n[b6-niacin-1995] Effects of Vitamin B6 Deficiency on the Conversion Ratio of Tryptophan to Niacin (1995). https://doi.org/10.1271/bbb.59.2060 DOI: 10.1271/bbb.59.2060","model_system":"Young male Wistar rats; four controlled diets for 19 days","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-niacin-1995] Effects of Vitamin B6 Deficiency on the Conversion Ratio of Tryptophan to Niacin (1995). https://doi.org/10.1271/bbb.59.2060 DOI: 10.1271/bbb.59.2060","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}