{"id":"4092f53d-c425-5c65-b7e1-2342f5654a95","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-human-depletion-route-boundary","predicate":"modulates","statement":"Five depleted subjects had impaired oral glucose tolerance; two tested intravenously did not, and insulin-resistance tests were negative.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"40c7c24e-49e6-5800-9fb2-f8d6cf564ac8","mechanism_event_label":"The measured glucose effect depended on the test and was mild.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"40c7c24e-49e6-5800-9fb2-f8d6cf564ac8","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-human-depletion-route-boundary-event","event_type":"biochemical_relationship","label":"The measured glucose effect depended on the test and was mild.","description":"Five depleted subjects had impaired oral glucose tolerance; two tested intravenously did not, and insulin-resistance tests were negative.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"test substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"response measure","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Seven experimentally depleted subjects, mean deficit 326 mEq; five oral and two intravenous glucose tests, followed by repletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different small subject groups, not randomized route comparison. No contradiction with a scoped clamp result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured glucose effect depended on the test and was mild.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gorden-1973-depletion] Glucose Intolerance with Hypokalemia: Failure of Short-term Potassium Depletion in Normal Subjects to Reproduce the Glucose and Insulin Abnormalities of Clinical Hypokalemia (1973). https://diabetesjournals.org/diabetes/article-pdf/22/7/544/347377/22-7-544.pdf DOI: 10.2337/diab.22.7.544","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic glucose regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"030bf02d-7ea4-5735-850b-59b585cc202a","evidence_kind":"source_excerpt","locator":"Lines 846-855","start_line":846,"end_line":855,"excerpt":"### k-human-depletion-route-boundary\nFive depleted subjects had impaired oral glucose tolerance; two tested intravenously did not, and insulin-resistance tests were negative.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured glucose effect depended on the test and was mild.\norganism: Human\ntissue_or_cell_type: Systemic glucose regulation\nexperimental_model: Seven experimentally depleted subjects, mean deficit 326 mEq; five oral and two intravenous glucose tests, followed by repletion.\nlimitations: Different small subject groups, not randomized route comparison. No contradiction with a scoped clamp result.\n[gorden-1973-depletion] Glucose Intolerance with Hypokalemia: Failure of Short-term Potassium Depletion in Normal Subjects to Reproduce the Glucose and Insulin Abnormalities of Clinical Hypokalemia (1973). https://diabetesjournals.org/diabetes/article-pdf/22/7/544/347377/22-7-544.pdf DOI: 10.2337/diab.22.7.544","model_system":"Seven experimentally depleted subjects, mean deficit 326 mEq; five oral and two intravenous glucose tests, followed by repletion.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [gorden-1973-depletion] Glucose Intolerance with Hypokalemia: Failure of Short-term Potassium Depletion in Normal Subjects to Reproduce the Glucose and Insulin Abnormalities of Clinical Hypokalemia (1973). https://diabetesjournals.org/diabetes/article-pdf/22/7/544/347377/22-7-544.pdf DOI: 10.2337/diab.22.7.544","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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