{"id":"402faef5-e1e8-5b2b-8320-01ccd4534d85","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-restriction-alone-not-sufficient-hypokalemia","predicate":"restriction-did-not-consistently-lower","statement":"Isolated Mg restriction produced hypomagnesemia without the hypokalemia observed under combined Na/Mg restriction in the tested mice.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"789a3543-a72f-5afa-939e-85d5856de587","mechanism_event_label":"A low Mg blood value alone did not guarantee falling potassium: sodium transport and the rest of the kidney response mattered.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"789a3543-a72f-5afa-939e-85d5856de587","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-restriction-alone-not-sufficient-hypokalemia-event","event_type":"observed_intervention","label":"A low Mg blood value alone did not guarantee falling potassium: sodium transport and the rest of the kidney response mattered.","description":"Isolated Mg restriction produced hypomagnesemia without the hypokalemia observed under combined Na/Mg restriction in the tested mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b6e8049f-ad5c-5ca0-ba73-1d4392131397","slug":"enac","display_name":"Epithelial sodium channel","entity_type_key":"protein_complex"},"role":"compensatory transport pathway","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"affected nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [maeoka-2025-enac-romk] Hypomagnesaemia-associated hypokalaemia requires activation of both ENaC and ROMK (2025). https://pubmed.ncbi.nlm.nih.gov/41137719/ DOI: 10.1113/JP287704","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}