{"id":"3fff4291-3feb-56d6-ba3d-28fb128c8254","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-armas-parent-appearance","predicate":"produces-similar-initial-appearance","statement":"The administered D2 and D3 produced similar initial rises in their respective parent calciferol serum concentrations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"815e6700-fc89-5898-b8d7-25a3d2195eec","mechanism_event_label":"The two forms entered the circulation similarly in this single-dose experiment.","subject":{"id":"1e377530-26da-59d9-99e7-3b15f86ea2b9","slug":"d2-d3-equal-dose-comparison","display_name":"Matched-dose D2 versus D3 comparison","entity_type_key":"cellular_process"},"object":{"id":"e745e444-27bf-50f6-b43a-05aa743a38d6","slug":"serum-parent-calciferol-concentration","display_name":"Serum administered parent calciferol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"815e6700-fc89-5898-b8d7-25a3d2195eec","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-armas-parent-appearance-event","event_type":"observed_intervention","label":"The two forms entered the circulation similarly in this single-dose experiment.","description":"The administered D2 and D3 produced similar initial rises in their respective parent calciferol serum concentrations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1e377530-26da-59d9-99e7-3b15f86ea2b9","slug":"d2-d3-equal-dose-comparison","display_name":"Matched-dose D2 versus D3 comparison","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e745e444-27bf-50f6-b43a-05aa743a38d6","slug":"serum-parent-calciferol-concentration","display_name":"Serum administered parent calciferol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human single-dose comparison; 20 healthy men; 28-day follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One oral 50, 000-IU dose of D2 or D3; serial serum measures for 28 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single 50, 000-IU dose in healthy men; biochemical response, not fracture efficacy. 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(2004). https://pubmed.ncbi.nlm.nih.gov/15531486/ DOI: 10.1210/jc.2004-0360","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"076b691f-7eef-5a5f-becc-1dcef78d6b23","evidence_kind":"source_excerpt","locator":"Lines 1223-1234","start_line":1223,"end_line":1234,"excerpt":"### vd-armas-parent-appearance\nThe administered D2 and D3 produced similar initial rises in their respective parent calciferol serum concentrations.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The two forms entered the circulation similarly in this single-dose experiment.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Human single-dose comparison; 20 healthy men; 28-day follow-up\nlimitations: Single 50, 000-IU dose in healthy men; biochemical response, not fracture efficacy. 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