{"id":"3ffe6f16-bd41-5bd2-9036-2c5cafc71a69","stable_key":"bf161ddf-8b82-5d65-b86d-0b41245aac61:phlorizin-quercetin-comparison","predicate":"differs_from","statement":"Glucosylation improved net quercetin absorption as isoquercitrin but reduced phloretin absorption as phlorizin, demonstrating substrate-specific effects of glycosylation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9ef96bd1-0a61-58fa-b1e8-34dbb818227a","mechanism_event_label":"Glucosylation improved net quercetin absorption as isoquercitrin but reduced phloretin absorption as phlorizin, demonstrating substrate-specific effects of glycosylation.","subject":{"id":"e0c57257-f198-5627-bf7a-f3fc0d2e4502","slug":"isoquercitrin","display_name":"Isoquercitrin / quercetin 3-O-glucoside","entity_type_key":"small_molecule"},"object":{"id":"3516a0ba-1f72-5e1b-bccb-7fca992f96f7","slug":"phlorizin","display_name":"Phlorizin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9ef96bd1-0a61-58fa-b1e8-34dbb818227a","stable_key":"bf161ddf-8b82-5d65-b86d-0b41245aac61:phlorizin-quercetin-comparison-event","event_type":"observed_relationship","label":"Glucosylation improved net quercetin absorption as isoquercitrin but reduced phloretin absorption as phlorizin, demonstrating substrate-specific effects of glycosylation.","description":"Glucosylation improved net quercetin absorption as isoquercitrin but reduced phloretin absorption as phlorizin, demonstrating substrate-specific effects of glycosylation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e0c57257-f198-5627-bf7a-f3fc0d2e4502","slug":"isoquercitrin","display_name":"Isoquercitrin / quercetin 3-O-glucoside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3516a0ba-1f72-5e1b-bccb-7fca992f96f7","slug":"phlorizin","display_name":"Phlorizin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2e17b6b4-ba3c-5167-89ed-a667f3cb808e","slug":"quercetin","display_name":"Quercetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"83949207-904f-53dc-bc9d-f7afaa546b34","slug":"phloretin","display_name":"Phloretin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Quercetin/isoquercitrin and phloretin/phlorizin pairs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"30 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Intestinal perfusion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Comparative flavonoid absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"02f4c4c4-fa23-59b0-8218-13352efedcb0","evidence_kind":"source_excerpt","locator":"Lines 66-75","start_line":66,"end_line":75,"excerpt":"## phlorizin-quercetin-comparison\nGlucosylation improved net quercetin absorption as isoquercitrin but reduced phloretin absorption as phlorizin, demonstrating substrate-specific effects of glycosylation.\nModel/species: In-situ rat intestinal perfusion\nTissue/system: Comparative flavonoid absorption\nExposure: Quercetin/isoquercitrin and phloretin/phlorizin pairs\nRoute: Intestinal perfusion\nDuration: 30 minutes\nLimits: This is a mechanistic nutrient-to-nutrient comparison in rats, not evidence that the flavonoids compete in humans.\nPrimary reference: Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"In-situ rat intestinal perfusion","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7d4bfcb9-1665-5686-8b8a-1ad17ad6a4d2","stable_key":"import-bf161ddf-8b82-5d65-b86d-0b41245aac61","title":"Phlorizin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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