{"id":"3ff25c66-e53d-52c8-b26e-bf3c92b7afd1","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-low-plp-prevalence","predicate":"reduces","statement":"Thirty-five of 66 alcoholic subjects selected for normal liver function and haematology had plasma PLP below 5 ng/ml, the lowest value found in 94 controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"78a869c7-711b-5b9c-ba80-cbb177579538","mechanism_event_label":"More than half had less of the active vitamin than any healthy control, with healthy livers.","subject":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"object":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"78a869c7-711b-5b9c-ba80-cbb177579538","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-low-plp-prevalence-event","event_type":"observed_intervention","label":"More than half had less of the active vitamin than any healthy control, with healthy livers.","description":"Thirty-five of 66 alcoholic subjects selected for normal liver function and haematology had plasma PLP below 5 ng/ml, the lowest value found in 94 controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"depleted_coenzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"depleted_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/4359937.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1df4485150b1be55f3e5214c424f960ff627cfc317e643c86a0f6747efed8b08\", \"start_char\": 0, \"end_char\": 1650, \"text_sha256\": \"1df4485150b1be55f3e5214c424f960ff627cfc317e643c86a0f6747efed8b08\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Plasma PLP in 66 alcoholic subjects without liver abnormality, plus erythrocyte enzyme assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic alcohol abuse; acetaldehyde and ethanol applied to erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selecting subjects without abnormal liver function isolates the vitamin effect from liver disease. The phosphatase mechanism is shown in erythrocytes, not liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More than half had less of the active vitamin than any healthy control, with healthy livers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p4359937] Vitamin B6 metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in human erythrocytes. (1974). https://pubmed.ncbi.nlm.nih.gov/4359937/ DOI: 10.1172/jci107607","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"32251773-cd4f-5df0-bce6-0ef328926244","evidence_kind":"source_excerpt","locator":"Lines 631-642","start_line":631,"end_line":642,"excerpt":"### alcohol-low-plp-prevalence\nThirty-five of 66 alcoholic subjects selected for normal liver function and haematology had plasma PLP below 5 ng/ml, the lowest value found in 94 controls.\nCondition category: nutrient_deficiency\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: More than half had less of the active vitamin than any healthy control, with healthy livers.\norganism: Human\ntissue_or_cell_type: Plasma and erythrocytes\nexperimental_model: Plasma PLP in 66 alcoholic subjects without liver abnormality, plus erythrocyte enzyme assays\nlimitations: Selecting subjects without abnormal liver function isolates the vitamin effect from liver disease. The phosphatase mechanism is shown in erythrocytes, not liver.\nexposure: Chronic alcohol abuse; acetaldehyde and ethanol applied to erythrocytes\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/4359937.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1df4485150b1be55f3e5214c424f960ff627cfc317e643c86a0f6747efed8b08\", \"start_char\": 0, \"end_char\": 1650, \"text_sha256\": \"1df4485150b1be55f3e5214c424f960ff627cfc317e643c86a0f6747efed8b08\"}\n[alcohol-p4359937] Vitamin B6 metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in human erythrocytes. (1974). https://pubmed.ncbi.nlm.nih.gov/4359937/ DOI: 10.1172/jci107607","model_system":"Plasma PLP in 66 alcoholic subjects without liver abnormality, plus erythrocyte enzyme assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p4359937] Vitamin B6 metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in human erythrocytes. 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