{"id":"3fa9b638-3d7e-50ec-84e8-4504fba7e8a5","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-adipocyte-uptake","predicate":"increases","statement":"Myricetin increased glucose uptake and lipogenesis in isolated rat adipocytes without detected insulin-receptor autophosphorylation or GLUT4 translocation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9f6574a5-671f-53d7-b77e-9ed245ac354e","mechanism_event_label":"Increased uptake need not mean more GLUT4 moved to the membrane.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"a1908c73-009a-583b-8216-b4e9247c6f2d","slug":"rat-adipocyte-glucose-uptake","display_name":"Rat adipocyte glucose uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9f6574a5-671f-53d7-b77e-9ed245ac354e","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-adipocyte-uptake-event","event_type":"observed_relationship","label":"Increased uptake need not mean more GLUT4 moved to the membrane.","description":"Myricetin increased glucose uptake and lipogenesis in isolated rat adipocytes without detected insulin-receptor autophosphorylation or GLUT4 translocation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a1908c73-009a-583b-8216-b4e9247c6f2d","slug":"rat-adipocyte-glucose-uptake","display_name":"Rat adipocyte glucose uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b355feba-1bd3-55d6-9f12-54b9fbadfd58","slug":"rat-slc2a4","display_name":"Rat glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated rat adipocytes; lipogenesis EC50 about 65 micromolar.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a universal insulin mimic; membrane transporter activity and tissue context matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Increased uptake need not mean more GLUT4 moved to the membrane.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8619886/ · DOI 10.1016/0006-2952(95)02195-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"feb0db05-be83-5e55-84bb-f457b5e6783e","evidence_kind":"source_excerpt","locator":"Lines 492-498","start_line":492,"end_line":498,"excerpt":"## myricetin-adipocyte-uptake\nIncreased uptake need not mean more GLUT4 moved to the membrane.\nMyricetin increased glucose uptake and lipogenesis in isolated rat adipocytes without detected insulin-receptor autophosphorylation or GLUT4 translocation.\nModel: Isolated rat adipocytes; lipogenesis EC50 about 65 micromolar.\nLimitations: Not a universal insulin mimic; membrane transporter activity and tissue context matter.\nEvidence access: Primary abstract\nInsulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8619886/ · DOI 10.1016/0006-2952(95)02195-7","model_system":"Isolated rat adipocytes; lipogenesis EC50 about 65 micromolar.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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