{"id":"3f55e94e-170b-5f74-87c8-abcc6c013272","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bpnt1-loss-translation","predicate":"loss_represses","statement":"Bpnt1-deficient mice showed repressed translation, abnormal nucleoli and liver injury.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7a682cb4-a22d-5dc2-9982-6c563e54388e","mechanism_event_label":"The accumulated by-product accompanied a failure of protein production.","subject":{"id":"a3f5210f-b74d-5335-ad89-d4b5d33dbd45","slug":"mouse-bpnt1","display_name":"Mouse bisphosphate nucleotidase 1 / Bpnt1","entity_type_key":"protein"},"object":{"id":"e7d42777-2431-5040-9948-e82d97281807","slug":"mouse-liver-protein-synthesis","display_name":"Mouse hepatic protein synthesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7a682cb4-a22d-5dc2-9982-6c563e54388e","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bpnt1-loss-translation-event","event_type":"observed_relationship","label":"The accumulated by-product accompanied a failure of protein production.","description":"Bpnt1-deficient mice showed repressed translation, abnormal nucleoli and liver injury.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3f5210f-b74d-5335-ad89-d4b5d33dbd45","slug":"mouse-bpnt1","display_name":"Mouse bisphosphate nucleotidase 1 / Bpnt1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e7d42777-2431-5040-9948-e82d97281807","slug":"mouse-liver-protein-synthesis","display_name":"Mouse hepatic protein synthesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c056d2b3-6cf8-500a-a641-1f19dd82cfd4","slug":"pap","display_name":"3-prime-Phosphoadenosine-5-prime-phosphate / PAP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse knockout; tissue-dependent phenotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that routine lithium treatment causes this knockout syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The accumulated by-product accompanied a failure of protein production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23479625/ · DOI 10.1073/pnas.1205001110","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2fa29f1e-6947-59a9-8f47-0e5504aeef81","evidence_kind":"source_excerpt","locator":"Lines 136-142","start_line":136,"end_line":142,"excerpt":"## lithium-bpnt1-loss-translation\nThe accumulated by-product accompanied a failure of protein production.\nBpnt1-deficient mice showed repressed translation, abnormal nucleoli and liver injury.\nModel: Mouse knockout; tissue-dependent phenotype.\nLimitations: Not evidence that routine lithium treatment causes this knockout syndrome.\nEvidence access: Primary abstract\nRole for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23479625/ · DOI 10.1073/pnas.1205001110","model_system":"Mouse knockout; tissue-dependent phenotype.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}