{"id":"3f51e10a-8b70-5267-993e-503a5bec16ff","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-acute-hf-limited-response","predicate":"does_not_consistently_improve","statement":"The acute-HF trial found no consistent benefit across dyspnea measurements or secondary outcomes in predominantly nondeficient participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"44ca0804-dac9-5675-a71c-d295bd8416fb","mechanism_event_label":"Routine supplementation did not produce a consistent symptom benefit in this population.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"244c326d-35c2-5516-9fff-3741d49d9b57","slug":"acute-heart-failure-dyspnea","display_name":"Dyspnea during acute heart failure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"44ca0804-dac9-5675-a71c-d295bd8416fb","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-acute-hf-limited-response-event","event_type":"observed_intervention","label":"Routine supplementation did not produce a consistent symptom benefit in this population.","description":"The acute-HF trial found no consistent benefit across dyspnea measurements or secondary outcomes in predominantly nondeficient participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"244c326d-35c2-5516-9fff-3741d49d9b57","slug":"acute-heart-failure-dyspnea","display_name":"Dyspnea during acute heart failure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"118 evaluable participants of 130 randomized; two-day intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"100 mg thiamine versus placebo on each of the first two evenings; outcomes eight hours after infusion; trial exposure only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"One sitting-on-oxygen dyspnea comparison was significant; other dyspnea measures and secondary outcomes were not. Only one participant was deficient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Routine supplementation did not produce a consistent symptom benefit in this population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-smithline2019] Supplemental thiamine for the treatment of acute heart failure syndrome: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31060559/ DOI: 10.1186/s12906-019-2506-8","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical symptoms","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9389371f-bdaf-5e8c-bd3a-512fd2514098","evidence_kind":"source_excerpt","locator":"Lines 1708-1718","start_line":1708,"end_line":1718,"excerpt":"### b1-acute-hf-limited-response\nThe acute-HF trial found no consistent benefit across dyspnea measurements or secondary outcomes in predominantly nondeficient participants.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Routine supplementation did not produce a consistent symptom benefit in this population.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical symptoms\nexperimental_model: 118 evaluable participants of 130 randomized; two-day intervention.\nlimitations: One sitting-on-oxygen dyspnea comparison was significant; other dyspnea measures and secondary outcomes were not. Only one participant was deficient.\nexposure: 100 mg thiamine versus placebo on each of the first two evenings; outcomes eight hours after infusion; trial exposure only.\n[b1-smithline2019] Supplemental thiamine for the treatment of acute heart failure syndrome: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31060559/ DOI: 10.1186/s12906-019-2506-8","model_system":"118 evaluable participants of 130 randomized; two-day intervention.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-smithline2019] Supplemental thiamine for the treatment of acute heart failure syndrome: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31060559/ DOI: 10.1186/s12906-019-2506-8","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}