{"id":"3efd18ff-af64-5a10-a345-c241200d8eb4","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-calcium","predicate":"increases","statement":"Urinary calcium excretion rose from 126 to 200 micrograms/min.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7902fd0f-47f0-5668-a174-53f43abcac15","mechanism_event_label":"Calcium did not follow the same urinary pattern as potassium and phosphate.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"3c05c499-627d-529e-ac31-fe169314e20d","slug":"renal-calcium-excretion","display_name":"Renal calcium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7902fd0f-47f0-5668-a174-53f43abcac15","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-calcium-event","event_type":"observed_relationship","label":"Calcium did not follow the same urinary pattern as potassium and phosphate.","description":"Urinary calcium excretion rose from 126 to 200 micrograms/min.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3c05c499-627d-529e-ac31-fe169314e20d","slug":"renal-calcium-excretion","display_name":"Renal calcium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Calcium did not follow the same urinary pattern as potassium and phosphate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6b9accd0-9c2e-5455-95a7-bfd57ef33e21","evidence_kind":"source_excerpt","locator":"Lines 472-478","start_line":472,"end_line":478,"excerpt":"## fast-insulin-calcium\nCalcium did not follow the same urinary pattern as potassium and phosphate.\nUrinary calcium excretion rose from 126 to 200 micrograms/min.\nModel: Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.\nLimitations: Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.\nEvidence access: Primary abstract\nThe effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","model_system":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}