{"id":"3ef1a857-0179-5cff-8609-2abd10eebacf","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-slc25a39-loss-peroxidation","predicate":"increases","statement":"SLC25A39 knockdown reportedly increased lipid peroxidation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"38487f26-3d25-500f-8630-ab6d7ddb8bae","mechanism_event_label":"crc slc25a39 loss peroxidation","subject":{"id":"23c0d087-9157-5f0c-bc89-805cd914df6c","slug":"human-crc-slc25a39-knockdown","display_name":"SLC25A39 knockdown in human colorectal cancer models","entity_type_key":"protein_state"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"38487f26-3d25-500f-8630-ab6d7ddb8bae","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:crc-slc25a39-loss-peroxidation","event_type":"increases","label":"crc slc25a39 loss peroxidation","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"23c0d087-9157-5f0c-bc89-805cd914df6c","slug":"human-crc-slc25a39-knockdown","display_name":"SLC25A39 knockdown in human colorectal cancer models","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"abstract_only","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Mitochondrial GSH versus intracellular GSH distinguished by authors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Unknown: full methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"lipid-peroxidation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract; experiment-specific methods unavailable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein interaction/stability, knockdown and compound experiments reported in abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"human-crc-slc25a39-knockdown","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"ABSTRACT-ONLY CURATION. Full article and supplements were not accessible; assay-specific cell line, dose, timing, controls and sample size remain unverified. No pulmonary-endothelial or clinical-treatment inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Topical cross-reference only; no inheritance of another actor's effects.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human colorectal cancer models; individual experiments require full-text confirmation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"SLC25A39 knockdown reportedly increased lipid peroxidation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_locator","value_text":"[{\"cache\": \"artifacts/dlat-curation/crc-metadata.json\", \"json_path\": \"resultList.result[0].abstractText\", \"access\": \"abstract_only\"}]","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"https://doi.org/10.1016/j.freeradbiomed.2026.04.133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Colorectal cancer models; claim-specific cell line not established from abstract","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8376511a-fe0b-5808-af7c-69bfc8f8d041","evidence_kind":"source_excerpt","locator":"Lines 835-849","start_line":835,"end_line":849,"excerpt":"SLC25A39 knockdown reportedly increased lipid peroxidation.\norganism: Human colorectal cancer models; individual experiments require full-text confirmation\ntissue_or_cell_type: Colorectal cancer models; claim-specific cell line not established from abstract\nexperimental_model: Protein interaction/stability, knockdown and compound experiments reported in abstract\ncompartment: Mitochondrial GSH versus intracellular GSH distinguished by authors\ndose: Unknown: full methods unavailable\nduration: Unknown: full methods unavailable\nprimary_references: https://doi.org/10.1016/j.freeradbiomed.2026.04.133\naccess_level: abstract_only\nevidence_location: Primary indexed abstract; experiment-specific methods unavailable\nendpoint: lipid-peroxidation\nexposure: human-crc-slc25a39-knockdown\nlimitations: ABSTRACT-ONLY CURATION. Full article and supplements were not accessible; assay-specific cell line, dose, timing, controls and sample size remain unverified. No pulmonary-endothelial or clinical-treatment inference.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/crc-metadata.json\", \"json_path\": \"resultList.result[0].abstractText\", \"access\": \"abstract_only\"}]\nplain_language: SLC25A39 knockdown reportedly increased lipid peroxidation.","model_system":"Protein interaction/stability, knockdown and compound experiments reported in abstract","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}