{"id":"3ee6bf3a-bd54-5ccd-858b-1b6ea84b9ffd","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-histidinemia-followup","predicate":"associates_with","statement":"Long-term follow-up of screen-detected histidinemia found normal growth, no relation of plasma histidine to DQ/IQ and no apparent benefit from early low-histidine diet.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5f6fb29a-1900-5a8b-be9e-e8817d5bbe57","mechanism_event_label":"Higher histidine from slow breakdown did not by itself predict developmental impairment in this cohort.","subject":{"id":"6593cb68-1166-59d9-b712-04f87ff05795","slug":"human-histidinemia","display_name":"Human histidinemia","entity_type_key":"cellular_process"},"object":{"id":"fad131f4-df1f-57b8-81f2-8bd2e6df9642","slug":"human-histidinemia-followup","display_name":"Development and growth in screen-detected histidinemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f6fb29a-1900-5a8b-be9e-e8817d5bbe57","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-histidinemia-followup-event","event_type":"observed_relationship","label":"Higher histidine from slow breakdown did not by itself predict developmental impairment in this cohort.","description":"Long-term follow-up of screen-detected histidinemia found normal growth, no relation of plasma histidine to DQ/IQ and no apparent benefit from early low-histidine diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6593cb68-1166-59d9-b712-04f87ff05795","slug":"human-histidinemia","display_name":"Human histidinemia","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fad131f4-df1f-57b8-81f2-8bd2e6df9642","slug":"human-histidinemia-followup","display_name":"Development and growth in screen-detected histidinemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1b502f98-4baa-530c-bc0f-31a38f740dd3","slug":"hal","display_name":"Human histidine ammonia-lyase / HAL","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"113 detected children, nine lost to follow-up; 47 historically treated before 1981, others untreated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational and nonrandom treatment allocation; not a general high-dose supplement safety study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Higher histidine from slow breakdown did not by itself predict developmental impairment in this cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Histidinaemia: a benign metabolic disorder. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8669938/ · DOI 10.1136/adc.74.4.343","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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