{"id":"3ec631e3-1bf1-5913-9f8d-465d6ea9e2e5","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-amodiaquine-pk-interaction","predicate":"alters","statement":"In twenty healthy volunteers, concurrent Moringa leaf powder lowered amodiaquine Cmax, while seven-day pretreatment increased desethylamodiaquine Cmax and AUC; desethylamodiaquine AUC rose 40.4% with concurrent dosing and 188% after pretreatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3ff55325-7d65-5954-8841-a1a8867aab79","mechanism_event_label":"In twenty healthy volunteers, concurrent Moringa leaf powder lowered amodiaquine Cmax, while seven-day pretreatment increased desethylamodiaquine Cmax and AUC; desethylamodiaquine AUC rose 40.4% with concurrent dosing and 188% after pretreatment.","subject":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"object":{"id":"6b7eb6b7-487f-5c9f-af99-defa9758a146","slug":"human-amodiaquine-desethylamodiaquine-exposure","display_name":"Human amodiaquine and desethylamodiaquine pharmacokinetic exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3ff55325-7d65-5954-8841-a1a8867aab79","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-amodiaquine-pk-interaction-event","event_type":"observed_relationship","label":"In twenty healthy volunteers, concurrent Moringa leaf powder lowered amodiaquine Cmax, while seven-day pretreatment increased desethylamodiaquine Cmax and AUC; desethylamodiaquine AUC rose 40.4% with concurrent dosing and 188% after pretreatment.","description":"In twenty healthy volunteers, concurrent Moringa leaf powder lowered amodiaquine Cmax, while seven-day pretreatment increased desethylamodiaquine Cmax and AUC; desethylamodiaquine AUC rose 40.4% with concurrent dosing and 188% after pretreatment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6b7eb6b7-487f-5c9f-af99-defa9758a146","slug":"human-amodiaquine-desethylamodiaquine-exposure","display_name":"Human amodiaquine and desethylamodiaquine pharmacokinetic exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d3f558ac-4832-588e-ab3b-a5bf41d4d4ca","slug":"amodiaquine","display_name":"Amodiaquine","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d71220f7-31ac-575a-aee8-7ec78d5d17fb","slug":"desethylamodiaquine","display_name":"Desethylamodiaquine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Single amodiaquine 10 mg/kg with concurrent 3 g Moringa or after 3 g/day for seven days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Concurrent dose or seven-day pretreatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2018). https://pubmed.ncbi.nlm.nih.gov/29920710/ DOI: 10.1111/jcpt.12725","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Amodiaquine and desethylamodiaquine plasma pharmacokinetics","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aeadb14f-1602-577f-b61a-9c107390bef5","evidence_kind":"source_excerpt","locator":"Lines 189-198","start_line":189,"end_line":198,"excerpt":"## moringa-amodiaquine-pk-interaction\nIn twenty healthy volunteers, concurrent Moringa leaf powder lowered amodiaquine Cmax, while seven-day pretreatment increased desethylamodiaquine Cmax and AUC; desethylamodiaquine AUC rose 40.4% with concurrent dosing and 188% after pretreatment.\nModel/species: Twenty healthy adults in a three-period study\nTissue/system: Amodiaquine and desethylamodiaquine plasma pharmacokinetics\nExposure: Single amodiaquine 10 mg/kg with concurrent 3 g Moringa or after 3 g/day for seven days\nRoute: Oral\nDuration: Concurrent dose or seven-day pretreatment\nLimits: Pharmacokinetic changes may not translate directly to efficacy or toxicity; the open sequence and specific powder schedule limit generalization.\nPrimary reference: Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers. (2018). https://pubmed.ncbi.nlm.nih.gov/29920710/ DOI: 10.1111/jcpt.12725\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Twenty healthy adults in a three-period study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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