{"id":"3e922d33-c337-5655-9de0-210187b8d264","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-depletion-skin","predicate":"was_associated_with","statement":"Five of seven men developed miliaria crystallina during the depletion experiment; it disappeared as repletion began.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4ad26e6f-2b14-5af5-aeae-78d0c9a9e32b","mechanism_event_label":"Severe restriction was accompanied by a reversible skin eruption in this small study.","subject":{"id":"dff9ac5c-2336-5ed3-a300-569bfc62a540","slug":"human-manganese-depletion-diet","display_name":"Controlled manganese-depletion diet","entity_type_key":"cellular_process"},"object":{"id":"0f27d0ff-c36c-56fa-98fc-777af00967df","slug":"miliaria-crystallina","display_name":"Miliaria crystallina skin eruption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4ad26e6f-2b14-5af5-aeae-78d0c9a9e32b","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-depletion-skin-event","event_type":"observed_intervention","label":"Severe restriction was accompanied by a reversible skin eruption in this small study.","description":"Five of seven men developed miliaria crystallina during the depletion experiment; it disappeared as repletion began.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dff9ac5c-2336-5ed3-a300-569bfc62a540","slug":"human-manganese-depletion-diet","display_name":"Controlled manganese-depletion diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f27d0ff-c36c-56fa-98fc-777af00967df","slug":"miliaria-crystallina","display_name":"Miliaria crystallina skin eruption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Manganese handling and the measured downstream function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/friedman1987.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6\", \"start_char\": 0, \"end_char\": 1186, \"text_sha256\": \"ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6\", \"text_characters\": 1186}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled depletion and repletion in seven men aged 19–22","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Three weeks at 2.59 mg Mn/day, then 39 days at 0.11 mg/day; repletion at 1.53 and 2.55 mg/day for five days each.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sequential purified-diet study without a parallel control. Findings are not diagnostic criteria; the paper’s factorial requirement estimates are not current recommended intakes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severe restriction was accompanied by a reversible skin eruption in this small study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-friedman1987] Manganese balance and clinical observations in young men fed a manganese-deficient diet. 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Findings are not diagnostic criteria; the paper’s factorial requirement estimates are not current recommended intakes.\nexposure: Three weeks at 2.59 mg Mn/day, then 39 days at 0.11 mg/day; repletion at 1.53 and 2.55 mg/day for five days each.\ncross_nutrient: Manganese handling and the measured downstream function.\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/friedman1987.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6\", \"start_char\": 0, \"end_char\": 1186, \"text_sha256\": \"ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6\", \"text_characters\": 1186}\n[mn-clin-friedman1987] Manganese balance and clinical observations in young men fed a manganese-deficient diet. 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