{"id":"3e19a016-4a84-5ba2-930d-e2528e77e272","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-gsh","predicate":"increases_tested","statement":"Ankaflavin increased glutathione measured in liver and pancreas of methylglyoxal-treated rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e2d283f3-831a-525d-bbd9-aaf700d380ad","mechanism_event_label":"Glutathione connects this pigment to shared amino-acid-dependent defenses.","subject":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"object":{"id":"f323b702-790b-505c-bb21-404ca4ea3b3d","slug":"rat-ankaflavin-tissue-gsh","display_name":"Rat hepatic and pancreatic glutathione during ankaflavin treatment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2d283f3-831a-525d-bbd9-aaf700d380ad","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-gsh-event","event_type":"observed_relationship","label":"Glutathione connects this pigment to shared amino-acid-dependent defenses.","description":"Ankaflavin increased glutathione measured in liver and pancreas of methylglyoxal-treated rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f323b702-790b-505c-bb21-404ca4ea3b3d","slug":"rat-ankaflavin-tissue-gsh","display_name":"Rat hepatic and pancreatic glutathione during ankaflavin treatment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"55c17a25-868a-5496-a200-88d9ec014558","slug":"methylglyoxal","display_name":"Methylglyoxal","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four-week Wistar rat model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish dietary cysteine demand, human glutathione repletion or which flux caused the concentration change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Glutathione connects this pigment to shared amino-acid-dependent defenses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4ab66302-a4a5-59d4-a6be-66db48de1d13","evidence_kind":"source_excerpt","locator":"Lines 260-266","start_line":260,"end_line":266,"excerpt":"## red-yeast-rice-ankaflavin-gsh\nGlutathione connects this pigment to shared amino-acid-dependent defenses.\nAnkaflavin increased glutathione measured in liver and pancreas of methylglyoxal-treated rats.\nModel: Four-week Wistar rat model.\nLimitations: Does not establish dietary cysteine demand, human glutathione repletion or which flux caused the concentration change.\nEvidence access: Primary abstract\n[23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025","model_system":"Four-week Wistar rat model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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