{"id":"3e10d11c-8f7e-55d8-bbe7-a4a37b6ac5a9","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ascorbate-context","predicate":"protects","statement":"With ascorbate present, resveratrol protected DNA in copper-based chemical experiments without lowering hydroxyl-radical formation rate, consistent with radical scavenging.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"34055ea4-09d9-5d53-be75-bc6d14af55e3","mechanism_event_label":"Vitamin C changes the relevant chemical context.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"ac9cd87f-025c-5386-a61b-d1b98b1fbb71","slug":"resveratrol-copper-ascorbate-dna","display_name":"DNA integrity in copper/ascorbate chemical assays","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"34055ea4-09d9-5d53-be75-bc6d14af55e3","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ascorbate-context-event","event_type":"observed_relationship","label":"Vitamin C changes the relevant chemical context.","description":"With ascorbate present, resveratrol protected DNA in copper-based chemical experiments without lowering hydroxyl-radical formation rate, consistent with radical scavenging.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac9cd87f-025c-5386-a61b-d1b98b1fbb71","slug":"resveratrol-copper-ascorbate-dna","display_name":"DNA integrity in copper/ascorbate chemical assays","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free DNA-bound copper system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Authors inferred physiological relevance; this experiment does not establish systemic safety or clinical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Vitamin C changes the relevant chemical context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11032413/ · DOI 10.1006/abbi.2000.1973","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"364fe4a1-2f03-5b01-b996-0279b78fd552","evidence_kind":"source_excerpt","locator":"Lines 374-380","start_line":374,"end_line":380,"excerpt":"## resveratrol-ascorbate-context\nVitamin C changes the relevant chemical context.\nWith ascorbate present, resveratrol protected DNA in copper-based chemical experiments without lowering hydroxyl-radical formation rate, consistent with radical scavenging.\nModel: Cell-free DNA-bound copper system.\nLimitations: Authors inferred physiological relevance; this experiment does not establish systemic safety or clinical synergy.\nEvidence access: Primary abstract\nEffects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11032413/ · DOI 10.1006/abbi.2000.1973","model_system":"Cell-free DNA-bound copper system.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}