{"id":"3d6900f4-58e1-58b7-8b17-fd86915be218","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-lymphocyte-micronuclei","predicate":"increases_in_test","statement":"CHD-FA increased micronucleus frequency in human lymphocyte testing under growth-inhibiting conditions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"40cb1b7d-eeb3-5002-b77f-50ff4c0e308a","mechanism_event_label":"One mammalian-cell test gave a positive signal.","subject":{"id":"5184fd06-5a8e-5e9d-99ec-c2feaa59ccde","slug":"carbohydrate-derived-fulvic-acid","display_name":"Carbohydrate-derived fulvic acid / CHD-FA (preparation class)","entity_type_key":"chemical_species"},"object":{"id":"351d1097-d496-5a62-bb28-5af53475134e","slug":"human-chdfa-lymphocyte-micronuclei","display_name":"Human lymphocyte micronucleus frequency after CHD-FA","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"40cb1b7d-eeb3-5002-b77f-50ff4c0e308a","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-lymphocyte-micronuclei-event","event_type":"observed_relationship","label":"One mammalian-cell test gave a positive signal.","description":"CHD-FA increased micronucleus frequency in human lymphocyte testing under growth-inhibiting conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5184fd06-5a8e-5e9d-99ec-c2feaa59ccde","slug":"carbohydrate-derived-fulvic-acid","display_name":"Carbohydrate-derived fulvic acid / CHD-FA (preparation class)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"351d1097-d496-5a62-bb28-5af53475134e","slug":"human-chdfa-lymphocyte-micronuclei","display_name":"Human lymphocyte micronucleus frequency after CHD-FA","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In-vitro lymphocyte assay with/without metabolic activation; acidic high-dose conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The 2026 study was electronically published June 21, with a December issue date. Negative results in one assay do not erase positive or uncertain findings in another; chronic exposure remains unresolved. Acidity is a proposed explanation, not a demonstrated causal resolution; no mechanistic follow-up isolated it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"One mammalian-cell test gave a positive signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Genotoxicity of Carbohydrate Derived Fulvic Acid. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42383226/ · DOI 10.1016/j.toxrep.2026.102298","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd9866d0-f115-596e-aeea-0d2102e49e57","evidence_kind":"source_excerpt","locator":"Lines 292-298","start_line":292,"end_line":298,"excerpt":"## fulvic-acid-lymphocyte-micronuclei\nOne mammalian-cell test gave a positive signal.\nCHD-FA increased micronucleus frequency in human lymphocyte testing under growth-inhibiting conditions.\nModel: In-vitro lymphocyte assay with/without metabolic activation; acidic high-dose conditions.\nLimitations: The 2026 study was electronically published June 21, with a December issue date. Negative results in one assay do not erase positive or uncertain findings in another; chronic exposure remains unresolved. Acidity is a proposed explanation, not a demonstrated causal resolution; no mechanistic follow-up isolated it.\nEvidence access: Primary full text\nGenotoxicity of Carbohydrate Derived Fulvic Acid. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42383226/ · DOI 10.1016/j.toxrep.2026.102298","model_system":"In-vitro lymphocyte assay with/without metabolic activation; acidic high-dose conditions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"52c2c3ee6bb23d943a40e1c39dd9de5cca7acd6efa72479cb824149e85cc7968","revision_id":"94dfc01b-c93e-55ff-8f48-bb2e9a1979f6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}