{"id":"3d646ba9-e6ac-5baf-abba-ec30f8542b55","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-renal-loading-rickets","predicate":"induces","statement":"Strontium-loaded drinking water at approximately 200 mg/kg/day caused growth-plate expansion, increased osteoid and reduced bone formation in rats with mild chronic renal failure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"00c8ae95-432e-5707-98b4-253912f562e7","mechanism_event_label":"High exposure with impaired renal function can disrupt growing-bone mineralization.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"1fd33465-4d73-5020-a915-df8631431618","slug":"rat-renal-failure-strontium-rickets","display_name":"Rickets during strontium loading in rats with chronic renal failure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"00c8ae95-432e-5707-98b4-253912f562e7","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-renal-loading-rickets-event","event_type":"observed_relationship","label":"High exposure with impaired renal function can disrupt growing-bone mineralization.","description":"Strontium-loaded drinking water at approximately 200 mg/kg/day caused growth-plate expansion, increased osteoid and reduced bone formation in rats with mild chronic renal failure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1fd33465-4d73-5020-a915-df8631431618","slug":"rat-renal-failure-strontium-rickets","display_name":"Rickets during strontium loading in rats with chronic renal failure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Growing renal-failure rats; 2, 6 or 12 weeks of loading.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High animal exposure and disease context; not a human intake threshold or strontium deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"High exposure with impaired renal function can disrupt growing-bone mineralization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Moderate strontium loading induces rickets in rats with mild chronic renal failure. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21654178/ · DOI 10.1159/000328329","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e5c07e32-0891-50fa-acfe-a3c56216c313","evidence_kind":"source_excerpt","locator":"Lines 326-332","start_line":326,"end_line":332,"excerpt":"## strontium-renal-loading-rickets\nHigh exposure with impaired renal function can disrupt growing-bone mineralization.\nStrontium-loaded drinking water at approximately 200 mg/kg/day caused growth-plate expansion, increased osteoid and reduced bone formation in rats with mild chronic renal failure.\nModel: Growing renal-failure rats; 2, 6 or 12 weeks of loading.\nLimitations: High animal exposure and disease context; not a human intake threshold or strontium deficiency.\nEvidence access: Primary abstract\nModerate strontium loading induces rickets in rats with mild chronic renal failure. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21654178/ · DOI 10.1159/000328329","model_system":"Growing renal-failure rats; 2, 6 or 12 weeks of loading.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}