{"id":"3d2d26da-eb35-5ee7-9f64-8c2bfdbb9f95","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-cox-gate","predicate":"inhibits_tested","statement":"Indomethacin or capsaicin pretreatment reduced glutamate-associated mucus and pH responses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"105d3b53-dafb-59fd-aac7-02ab2942fd4b","mechanism_event_label":"Mediator synthesis and afferent function constrain the response.","subject":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"object":{"id":"0a3bae8e-2b2a-5622-86d8-07ede588684c","slug":"rat-duodenal-mucus-gel","display_name":"Rat duodenal mucus gel thickness","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"105d3b53-dafb-59fd-aac7-02ab2942fd4b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-cox-gate-event","event_type":"observed_relationship","label":"Mediator synthesis and afferent function constrain the response.","description":"Indomethacin or capsaicin pretreatment reduced glutamate-associated mucus and pH responses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0a3bae8e-2b2a-5622-86d8-07ede588684c","slug":"rat-duodenal-mucus-gel","display_name":"Rat duodenal mucus gel thickness","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"8427ecb2-ca50-5973-907e-be8f910ed68d","slug":"rat-duodenal-epithelial-ph","display_name":"Rat duodenal epithelial intracellular pH","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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