{"id":"3c8cece7-055b-53ec-b99a-907dd2860c51","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-caffeine-n2-p300","predicate":"increases","statement":"The combination produced greater N2-P300 amplitude than either single ingredient in the experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4f4a9a9e-52da-5cb5-adc1-75366237bc12","mechanism_event_label":"A stronger combined response does not by itself prove synergy.","subject":{"id":"e5828a6d-7d95-5d89-853e-3a591dcad6b8","slug":"theanine-caffeine-combination","display_name":"L-Theanine plus caffeine, study-specific combination","entity_type_key":"chemical_species"},"object":{"id":"514d114f-cfd8-50d2-9e03-87e8ff641029","slug":"n2-p300-amplitude","display_name":"Attention-task N2-P300 event-related potential amplitude","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4f4a9a9e-52da-5cb5-adc1-75366237bc12","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-caffeine-n2-p300-event","event_type":"observed_intervention","label":"A stronger combined response does not by itself prove synergy.","description":"The combination produced greater N2-P300 amplitude than either single ingredient in the experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"component","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e5828a6d-7d95-5d89-853e-3a591dcad6b8","slug":"theanine-caffeine-combination","display_name":"L-Theanine plus caffeine, study-specific combination","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"514d114f-cfd8-50d2-9e03-87e8ff641029","slug":"n2-p300-amplitude","display_name":"Attention-task N2-P300 event-related potential amplitude","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/26869148.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e57a4cbb05f109037735324857cc3fc4ac55dd8cb76f50979e820a1da52bd60\", \"start_char\": 0, \"end_char\": 1813, \"text_sha256\": \"9e57a4cbb05f109037735324857cc3fc4ac55dd8cb76f50979e820a1da52bd60\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Five-way crossover visual discrimination experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 mg theanine, 160 mg caffeine, combination, tea and placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small acute study. Larger combination effects were interpreted as additive; statistical interaction was not significant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"20 healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A stronger combined response does not by itself prove synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p26869148] Acute effects of theanine, caffeine and theanine-caffeine combination on attention. 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Larger combination effects were interpreted as additive; statistical interaction was not significant.\nexposure: 200 mg theanine, 160 mg caffeine, combination, tea and placebo\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/26869148.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e57a4cbb05f109037735324857cc3fc4ac55dd8cb76f50979e820a1da52bd60\", \"start_char\": 0, \"end_char\": 1813, \"text_sha256\": \"9e57a4cbb05f109037735324857cc3fc4ac55dd8cb76f50979e820a1da52bd60\"}\n[theanine-p26869148] Acute effects of theanine, caffeine and theanine-caffeine combination on attention. (2017). https://pubmed.ncbi.nlm.nih.gov/26869148/ DOI: 10.1080/1028415x.2016.1144845","model_system":"Five-way crossover visual discrimination experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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