{"id":"3c67e717-9b49-5568-acfd-d135bca4fbb6","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-ab-remodel","predicate":"remodels","statement":"EGCG bound mature fibrils and remodeled them into smaller amorphous aggregates without measured release of monomers or small diffusible oligomers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4a904652-7bd3-5e6d-896e-ee2e9b4a5192","mechanism_event_label":"EGCG changed pre-existing aggregates in a laboratory experiment.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"f2b6bdc9-76e1-5cd8-b893-e18d774403a5","slug":"amyloid-beta-fibrils","display_name":"Amyloid-beta fibrils, sequence specified by study","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"4a904652-7bd3-5e6d-896e-ee2e9b4a5192","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-ab-remodel-event","event_type":"observed_relationship","label":"EGCG changed pre-existing aggregates in a laboratory experiment.","description":"EGCG bound mature fibrils and remodeled them into smaller amorphous aggregates without measured release of monomers or small diffusible oligomers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b6bdc9-76e1-5cd8-b893-e18d774403a5","slug":"amyloid-beta-fibrils","display_name":"Amyloid-beta fibrils, sequence specified by study","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Mature amyloid-beta and alpha-synuclein fibril preparations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not show removal of deposits from a human brain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"EGCG changed pre-existing aggregates in a laboratory experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20385841/ · DOI 10.1073/pnas.0910723107","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7e07d48d-c9d0-520c-a45a-b00afda908cc","evidence_kind":"source_excerpt","locator":"Lines 356-362","start_line":356,"end_line":362,"excerpt":"## egcg-ab-remodel\nEGCG changed pre-existing aggregates in a laboratory experiment.\nEGCG bound mature fibrils and remodeled them into smaller amorphous aggregates without measured release of monomers or small diffusible oligomers.\nModel: Mature amyloid-beta and alpha-synuclein fibril preparations.\nLimitations: This does not show removal of deposits from a human brain.\nEvidence access: primary abstract.\nEGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20385841/ · DOI 10.1073/pnas.0910723107","model_system":"Mature amyloid-beta and alpha-synuclein fibril preparations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}