{"id":"3c565dca-8e71-51f3-b2a0-6d396f754e7c","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pth-ffar2","predicate":"supports","statement":"The permissive butyrate response involved GPR43 signaling in dendritic cells and GPR43-independent effects in T cells in the PTH study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d80f625c-7802-531c-b209-93b60dfd1e6a","mechanism_event_label":"The same pathway used different signaling routes in different immune cells.","subject":{"id":"58254c69-6891-50a3-a019-41aa81d6c361","slug":"mouse-ffar2","display_name":"Mouse free fatty acid receptor 2 / Ffar2","entity_type_key":"protein"},"object":{"id":"878ea010-e9a2-5f23-8b59-1a0abc38977e","slug":"mouse-ipth-bone-anabolism","display_name":"Mouse bone-anabolic response to intermittent PTH","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d80f625c-7802-531c-b209-93b60dfd1e6a","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pth-ffar2-event","event_type":"observed_relationship","label":"The same pathway used different signaling routes in different immune cells.","description":"The permissive butyrate response involved GPR43 signaling in dendritic cells and GPR43-independent effects in T cells in the PTH study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"58254c69-6891-50a3-a019-41aa81d6c361","slug":"mouse-ffar2","display_name":"Mouse free fatty acid receptor 2 / Ffar2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"878ea010-e9a2-5f23-8b59-1a0abc38977e","slug":"mouse-ipth-bone-anabolism","display_name":"Mouse bone-anabolic response to intermittent PTH","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"24f2ec5a-b6dd-5e40-bd54-b5650827ef07","slug":"mouse-wnt10b","display_name":"Mouse Wnt family member 10B / Wnt10b","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse cell-specific receptor and PTH experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not assign every T-cell butyrate response to FFAR2.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same pathway used different signaling routes in different immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31917685/ · DOI 10.1172/JCI133473","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"93acea71-1679-5e0a-a874-2ccebc057df7","evidence_kind":"source_excerpt","locator":"Lines 494-500","start_line":494,"end_line":500,"excerpt":"## butyrate-pth-ffar2\nThe same pathway used different signaling routes in different immune cells.\nThe permissive butyrate response involved GPR43 signaling in dendritic cells and GPR43-independent effects in T cells in the PTH study.\nModel: Mouse cell-specific receptor and PTH experiments.\nLimitations: Do not assign every T-cell butyrate response to FFAR2.\nEvidence access: Primary abstract\nParathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31917685/ · DOI 10.1172/JCI133473","model_system":"Mouse cell-specific receptor and PTH experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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