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Matrix trapping is the authors mechanism inferred with transport evidence. This recent study complements import findings; bacterial export does not reproduce mitochondrial topology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat H9c2 cells; human SLC25A3 in Lactococcus lactis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Copper misrouting also affected enzymes that depend on iron-sulfur clusters.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p42308035] SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis. 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Matrix trapping is the authors mechanism inferred with transport evidence. This recent study complements import findings; bacterial export does not reproduce mitochondrial topology.\nexposure: Slc25a3 deletion and elesclomol-copper exposure\nevidence_span: {\"source_cache\": \"artifacts/copper-research/42308035.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0c19d3c109f1df88791ad51c22e6acf85b7d5ffe5c26c74aaaf5e3222a75c054\", \"start_char\": 4157, \"end_char\": 4553, \"text_sha256\": \"458c46d27cddab000b77009e2f8f1d373871eaa90d0571867d421984ecd9803a\"}\n[copper-p42308035] SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis. 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