{"id":"3bed50dd-40cf-57b8-a933-a494bd6b24a2","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-ck2","predicate":"inhibits","statement":"Myricetin inhibited reconstituted human CK2 alpha-prime/beta holoenzyme, IC50 1.18 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f096c918-ec9d-5934-ae64-e3145992fe01","mechanism_event_label":"The same canonical kinase can connect multiple flavonoid chapters.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"8c3eb79c-4a30-5a53-a409-e1c4a4cea639","slug":"human-ck2-alpha-prime-holoenzyme","display_name":"Human CK2 alpha-prime/beta reconstituted holoenzyme","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"f096c918-ec9d-5934-ae64-e3145992fe01","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-ck2-event","event_type":"observed_relationship","label":"The same canonical kinase can connect multiple flavonoid chapters.","description":"Myricetin inhibited reconstituted human CK2 alpha-prime/beta holoenzyme, IC50 1.18 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8c3eb79c-4a30-5a53-a409-e1c4a4cea639","slug":"human-ck2-alpha-prime-holoenzyme","display_name":"Human CK2 alpha-prime/beta reconstituted holoenzyme","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a834a865-12fd-597a-85cf-c0a5571a4b82","slug":"csnk2a2","display_name":"Human CK2 alpha-prime / CSNK2A2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8b31ccee-d086-5cab-955f-9f14793b2255","slug":"csnk2b","display_name":"Human CK2 beta / CSNK2B","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human subunits; radiolabeled ATP incorporation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a measured therapeutic human exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same canonical kinase can connect multiple flavonoid chapters.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19197122/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"059b218a-8952-5610-8444-e225b5fd314c","evidence_kind":"source_excerpt","locator":"Lines 484-490","start_line":484,"end_line":490,"excerpt":"## myricetin-ck2\nThe same canonical kinase can connect multiple flavonoid chapters.\nMyricetin inhibited reconstituted human CK2 alpha-prime/beta holoenzyme, IC50 1.18 micromolar.\nModel: Recombinant human subunits; radiolabeled ATP incorporation.\nLimitations: Not a measured therapeutic human exposure.\nEvidence access: Primary abstract\nStructure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19197122/","model_system":"Recombinant human subunits; radiolabeled ATP incorporation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}