{"id":"3bc7ebd1-0aa8-535e-9eb2-1ee9b281a32c","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-agmatine","predicate":"contributes_carbon_to","statement":"Arginine-derived tracer also appeared in agmatine, without suppression by the arginase inhibitor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7170f36b-a933-52a7-b7a0-e07fed7941c3","mechanism_event_label":"A separate metabolic branch remained detectable.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"7170f36b-a933-52a7-b7a0-e07fed7941c3","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-agmatine-event","event_type":"observed_relationship","label":"A separate metabolic branch remained detectable.","description":"Arginine-derived tracer also appeared in agmatine, without suppression by the arginase inhibitor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human activated T cells; isotope tracing and functional assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The responsible enzyme was not established here; no universal human arginine-decarboxylase assignment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A separate metabolic branch remained detectable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"19d70580-1c84-52c7-b5a2-e13d0bff17bb","evidence_kind":"source_excerpt","locator":"Lines 230-236","start_line":230,"end_line":236,"excerpt":"## arg-tcell-agmatine\nA separate metabolic branch remained detectable.\nArginine-derived tracer also appeared in agmatine, without suppression by the arginase inhibitor.\nModel: Primary human activated T cells; isotope tracing and functional assays.\nLimitations: The responsible enzyme was not established here; no universal human arginine-decarboxylase assignment.\nEvidence access: Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.\nL-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","model_system":"Primary human activated T cells; isotope tracing and functional assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}