{"id":"3bc4e1d0-0257-5a88-9ac3-5e9a5acbe307","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-metabolism","predicate":"shifts","statement":"Higher arginine shifted activated T cells toward oxidative phosphorylation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"362f9664-96be-59f6-89f3-b35396c38531","mechanism_event_label":"Availability changed cellular fuel use.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"a230c6c4-b700-5358-8faa-5bb3bee6cd59","slug":"t-cell-oxidative-metabolism","display_name":"Oxidative metabolic program in activated T cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"362f9664-96be-59f6-89f3-b35396c38531","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-metabolism-event","event_type":"observed_relationship","label":"Availability changed cellular fuel use.","description":"Higher arginine shifted activated T cells toward oxidative phosphorylation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a230c6c4-b700-5358-8faa-5bb3bee6cd59","slug":"t-cell-oxidative-metabolism","display_name":"Oxidative metabolic program in activated T cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"79f00b93-428e-50ae-97a2-dd18af0d5387","slug":"intracellular-arginine-availability","display_name":"Intracellular free L-arginine availability","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human activated T cells; isotope tracing and functional assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human supplementation efficacy trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Availability changed cellular fuel use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2ba57c80-ef9f-58a7-91bd-503799c677e9","evidence_kind":"source_excerpt","locator":"Lines 238-244","start_line":238,"end_line":244,"excerpt":"## arg-tcell-metabolism\nAvailability changed cellular fuel use.\nHigher arginine shifted activated T cells toward oxidative phosphorylation.\nModel: Primary human activated T cells; isotope tracing and functional assays.\nLimitations: Not a human supplementation efficacy trial.\nEvidence access: Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.\nL-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","model_system":"Primary human activated T cells; isotope tracing and functional assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}