{"id":"3b182d6e-e569-550e-b89e-8a8b0e321b32","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-bioaccessibility","predicate":"is_bioaccessible_in_assay","statement":"Cinnamaldehyde showed reported 100% bioaccessibility in the simulated fasted and fed gastric/intestinal fluids.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"96803f13-6213-5a50-a8cb-0b64eb270ffc","mechanism_event_label":"It remained accessible in simulated digestion; this does not mean all of it reaches human blood unchanged.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"cc13e0ec-a221-5f29-8360-9ed6fc1565a7","slug":"cinnamaldehyde-simulated-bioaccessibility","display_name":"Cinnamaldehyde bioaccessibility in simulated digestive fluids","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"96803f13-6213-5a50-a8cb-0b64eb270ffc","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-bioaccessibility-event","event_type":"observed_intervention","label":"It remained accessible in simulated digestion; this does not mean all of it reaches human blood unchanged.","description":"Cinnamaldehyde showed reported 100% bioaccessibility in the simulated fasted and fed gastric/intestinal fluids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc13e0ec-a221-5f29-8360-9ed6fc1565a7","slug":"cinnamaldehyde-simulated-bioaccessibility","display_name":"Cinnamaldehyde bioaccessibility in simulated digestive fluids","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/39845339.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\", \"start_char\": 0, \"end_char\": 1463, \"text_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Simulated digestion and human liver microsomal/S9 metabolism","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cinnamaldehyde alone or in the characterized C. verum oil","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bioaccessibility is not systemic bioavailability; the oxidation data do not assign a unique aldehyde-dehydrogenase isoform.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human-derived preparations and acellular digestive fluids","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"It remained accessible in simulated digestion; this does not mean all of it reaches human blood unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastric/intestinal simulations; liver fractions","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4472bda7-15c5-5508-be5a-f4872bbe41ba","evidence_kind":"source_excerpt","locator":"Lines 259-270","start_line":259,"end_line":270,"excerpt":"### ceylon-bioaccessibility\nCinnamaldehyde showed reported 100% bioaccessibility in the simulated fasted and fed gastric/intestinal fluids.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: It remained accessible in simulated digestion; this does not mean all of it reaches human blood unchanged.\norganism: Human-derived preparations and acellular digestive fluids\ntissue_or_cell_type: Gastric/intestinal simulations; liver fractions\nexperimental_model: Simulated digestion and human liver microsomal/S9 metabolism\nlimitations: Bioaccessibility is not systemic bioavailability; the oxidation data do not assign a unique aldehyde-dehydrogenase isoform.\nexposure: Cinnamaldehyde alone or in the characterized C. verum oil\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/39845339.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\", \"start_char\": 0, \"end_char\": 1463, \"text_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\"}\n[ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","model_system":"Simulated digestion and human liver microsomal/S9 metabolism","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}